早产与青少年尿酸水平升高有关。
Preterm Birth Is Associated with Higher Uric Acid Levels in Adolescents.
作者信息
Washburn Lisa K, Nixon Patricia A, Russell Gregory B, Snively Beverly M, O'Shea T Michael
机构信息
Department of Pediatrics, Wake Forest University, Winston-Salem, NC.
Department of Pediatrics, Wake Forest University, Winston-Salem, NC; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC.
出版信息
J Pediatr. 2015 Jul;167(1):76-80. doi: 10.1016/j.jpeds.2015.03.043. Epub 2015 Apr 11.
OBJECTIVE
To compare serum uric acid levels in adolescents born prematurely and adolescents born at term and to assess the correlation between serum uric acid and blood pressure (BP) in those born prematurely.
STUDY DESIGN
In this observational cohort study, 124 adolescents born prematurely and 44 adolescents born at term were studied at 14 years of age. Multivariate analyses were used to describe the relationship of premature birth to serum uric acid while adjusting for confounding variables. Pearson correlation was used to describe the relationship between uric acid and systolic BP among those born prematurely.
RESULTS
Adjusting for race, sex, maternal hypertension, and fetal growth, we found that preterm adolescents had greater serum uric acid levels than adolescents born at term (adjusted mean difference 0.46, 95% CI 0.10-0.81 mg/dL; 27.4, 6-48.2 μmol/L; P = .012). Among those born prematurely, uric acid was positively correlated with systolic BP (Pearson correlation coefficient: 0.29, 0.12-0.44; P = .0013).
CONCLUSIONS
Serum uric acid levels are greater in adolescents born prematurely than in those born at term, and this difference could contribute to greater BP among individuals born prematurely.
目的
比较早产青少年和足月出生青少年的血清尿酸水平，并评估早产青少年血清尿酸与血压（BP）之间的相关性。
研究设计
在这项观察性队列研究中，对124名早产青少年和44名足月出生青少年在14岁时进行了研究。在调整混杂变量的同时，采用多变量分析来描述早产与血清尿酸之间的关系。使用Pearson相关性分析来描述早产青少年中尿酸与收缩压之间的关系。
结果
在对种族、性别、母亲高血压和胎儿生长情况进行调整后，我们发现早产青少年的血清尿酸水平高于足月出生的青少年（调整后的平均差异为0.46，95%置信区间为0.10 - 0.81mg/dL；27.4，6 - 48.2μmol/L；P = 0.012）。在早产青少年中，尿酸与收缩压呈正相关（Pearson相关系数：0.29，0.12 - 0.44；P = 0.0013）。
结论
早产青少年的血清尿酸水平高于足月出生的青少年，这种差异可能导致早产个体的血压更高。
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