Department of Clinical Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Front Endocrinol (Lausanne). 2021 Dec 3;12:773820. doi: 10.3389/fendo.2021.773820. eCollection 2021.
This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents.
A total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 to January 2019 were recruited for this retrospective study. We classified participants into two groups on the basis of HOMA-IR values: the low HOMA-IR group (< 3.16) (n = 222) and the high HOMA-IR group (≥ 3.16) (n = 147).
The univariate analysis found that the high HOMA-IR group had higher BMI, SUA, and fasting insulin (FINS) ( 0.05). Multiple linear regression analysis and mediating effect analysis indicated that body mass index (BMI) could directly regulate FINS and HOMA-IR (both 0.05). The results from the mediating effect analysis found that UA partially played an indirect role in the link between BMI, FINS and HOMA-IR (both 0.05) but had no effect on fasting blood glucose ( 0.05).
SUA should be investigated in obesity and plays a partial mediating role in insulin resistance induced by obesity in obese children and adolescents.
本研究旨在评估血清尿酸（SUA）是否在肥胖儿童和青少年胰岛素抵抗（IR）的发展中起介导作用。
本回顾性研究共纳入 2012 年 1 月至 2019 年 1 月在新华医院营养门诊就诊的肥胖儿童和青少年 369 例。根据 HOMA-IR 值将参与者分为两组：低 HOMA-IR 组（<3.16）（n=222）和高 HOMA-IR 组（≥3.16）（n=147）。
单因素分析发现，高 HOMA-IR 组的 BMI、SUA 和空腹胰岛素（FINS）均较高（P<0.05）。多元线性回归分析和中介效应分析表明，体重指数（BMI）可直接调节 FINS 和 HOMA-IR（均 P<0.05）。中介效应分析结果发现，UA 部分介导了 BMI、FINS 和 HOMA-IR 之间的联系（均 P<0.05），但对空腹血糖无影响（P>0.05）。
SUA 应在肥胖中进行调查，并在肥胖儿童和青少年肥胖引起的胰岛素抵抗中起部分介导作用。
