建立一种标准化的腹腔镜盲肠切除术模型，以模拟大鼠腹腔镜阑尾切除术。
Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats.
机构信息
Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
出版信息
Eur J Med Res. 2014 Jun 17;19(1):33. doi: 10.1186/2047-783X-19-33.
BACKGROUND
Laparoscopic appendectomy (LA) has become one of the most common surgical procedures to date. To improve and standardize this technique further, cost-effective and reliable animal models are needed.
METHODS
In a pilot study, 30 Wistar rats underwent laparoscopic caecum resection (as rats do not have an appendix vermiformis), to optimize the instrumental and surgical parameters. A subsequent test study was performed in another 30 rats to compare three different techniques for caecum resection and bowel closure.
RESULTS
Bipolar coagulation led to an insufficiency of caecal stump closure in all operated rats (Group 1, n = 10). Endoloop ligation followed by bipolar coagulation and resection (Group 2, n = 10) or resection with a LigaSure™ device (Group 3, n = 10) resulted in sufficient caecal stump closure.
CONCLUSIONS
We developed a LA model enabling us to compare three different caecum resection techniques in rats. In conclusion, only endoloop closure followed by bipolar coagulation proved to be a secure and cost-effective surgical approach.
背景
腹腔镜阑尾切除术（LA）已成为目前最常见的手术之一。为了进一步改进和规范这项技术，需要具有成本效益和可靠性的动物模型。
方法
在一项初步研究中，30 只 Wistar 大鼠接受了腹腔镜盲肠切除术（因为大鼠没有阑尾），以优化仪器和手术参数。随后在另外 30 只大鼠中进行了一项测试研究，比较了三种不同的盲肠切除术和肠闭合技术。
结果
在所有接受手术的大鼠中，双极电凝导致盲肠残端闭合不足（第 1 组，n=10）。肠套环结扎后再行双极电凝和切除（第 2 组，n=10）或使用 LigaSure™ 装置切除（第 3 组，n=10）可使盲肠残端闭合充分。
结论
我们开发了一种 LA 模型，使我们能够在大鼠中比较三种不同的盲肠切除术技术。总之，只有肠套环闭合后再行双极电凝被证明是一种安全且具有成本效益的手术方法。
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