从深海来源的索马里链霉菌SCSIO ZH66的wbl基因突变体中分离得到的一种新的二元酸。
A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66.
作者信息
Huang Huiming, Li Huayue, Qiu Yanhong, Hou Lukuan, Ju Jianhua, Li Wenli
机构信息
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
出版信息
Mar Drugs. 2016 Oct 17;14(10):184. doi: 10.3390/md14100184.
The gene functions as a global regulatory gene in a negative manner in deepsea-derived SCSIO ZH66. A new dioic acid () as well as two known butenolides ( and ) were isolated from the mutant strain of SCSIO ZH66. The structure of was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC value of 19.4 μg/mL, while compounds and showed null activity up to 100 μg/mL.
该基因在深海来源的SCSIO ZH66中作为一个负向全局调控基因发挥作用。从SCSIO ZH66的突变菌株中分离出一种新的二元酸（）以及两种已知的丁烯内酯（和）。通过包括质谱和核磁共振技术在内的光谱分析相结合的方法阐明了的结构。在细胞生长抑制评估中，化合物对人肝癌细胞系（Huh7.5）表现出中等活性，IC值为19.4 μg/mL，而化合物和在高达100 μg/mL时显示无活性。
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