Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, P. R. China.
Department of Pharmacy, Guangzhou General Hospital of, Guangzhou Military Command, Guangzhou, 510010, P. R. China.
Chem Biodivers. 2020 May;17(5):e2000022. doi: 10.1002/cbdv.202000022. Epub 2020 Apr 6.
Three new butenolides, caulerpalide A and a pair of enantiomers, (+)-caulerpalide B and (-)-caulerpalide B, together with seven known compounds, have been isolated from the green alga Caulerpa racemosa var. turbinata. All these structures were determined by spectroscopic techniques. The absolute configurations of caulerpalide A, (+)-caulerpalide B and (-)-caulerpalide B were elucidated by the method of ECD calculation. This is the first separation of butenolides from the algae of genus Caulerpa. Additionally, the antibacterial activities of the nine isolated compounds were also evaluated.
从绿藻 Caulerpa racemosa var. turbinata 中分离得到三个新的丁烯内酯化合物，分别为 caul-erpalide A 以及 (+)-caulerpalide B 和 (-)-caulerpalide B 一对对映异构体，同时还分离得到 7 个已知化合物。所有这些结构均通过光谱技术确定。通过 ECD 计算方法阐明了 caul-erpalide A、(+)-caulerpalide B 和 (-)-caulerpalide B 的绝对构型。这是首次从 Caulerpa 属藻类中分离出丁烯内酯。此外，还评估了 9 种分离化合物的抗菌活性。
