Lin Sheng-Hsiang, Liao Yu-Shu, Huang Shih-Horng, Liao Wan-Hsiu
Department of Internal Medicine, New Taipei City Hospital, No. 3, Section 1, New Taipei Boulevard, San-Chong District, New Taipei 24141, Taiwan; Department of Respiratory Therapy, Fu-Jen Catholic University, No. 510, Zhong-Zheng Road, Xin-Zhuang District, New Taipei 24205, Taiwan.
Department of Prosthodontic, Chang-Gung Memorial Hospital, No. 199, Tung-Hwa North Road, Song-Shan District, Taipei 10507, Taiwan.
Drug Alcohol Depend. 2014 Aug 1;141:132-7. doi: 10.1016/j.drugalcdep.2014.05.020. Epub 2014 Jun 3.
The association between betel quid (BQ) chewing and oral cancer is well established. However, evidence regarding the relationship between BQ chewing and cardiovascular disease (CVD) is still insufficient.
This cross-sectional study included 2002 men and 1175 women aged 50 and older in a city-level health examination survey of an agricultural and fishing population in 2013. In addition to anthropometric parameters, CVD risks were estimated using high-sensitivity C-reactive protein (hs-CRP), brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index. Age, gender, smoking and alcohol drinking status were all incorporated into the multivariate logistic regression model to delineate the effect of BQ chewing on CVD risks.
Two hundred forty-one (12%) males and eight (0.7%) females were ever chewers. BQ chewing was an independent risk factor for general obesity (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.07-1.91, p=0.017), central obesity (OR 2.27, 95% CI 1.53-3.37, p<0.001) and an elevated hs-CRP level (OR 1.38, 95% CI 1.03-1.85, p=0.029). Subjects who chewed more frequently had a higher systolic blood pressure (p=0.025) and baPWV (p=0.006). The waist circumference (p=0.015) and waist-to-height ratio (p=0.022) were greater in current chewers than in former chewers.
These findings suggest that BQ chewing is associated with obesity and a higher CVD risk as estimated by hs-CRP. Furthermore, potential beneficial effects of BQ chewing cessation on central obesity were also found.
嚼食槟榔与口腔癌之间的关联已得到充分证实。然而，关于嚼食槟榔与心血管疾病（CVD）之间关系的证据仍不充分。
这项横断面研究纳入了2013年对一个农业和渔业人口进行的市级健康检查调查中的2002名50岁及以上男性和1175名50岁及以上女性。除人体测量参数外，还使用高敏C反应蛋白（hs-CRP）、臂踝脉搏波速度（baPWV）和踝臂指数来评估心血管疾病风险。年龄、性别、吸烟和饮酒状况均纳入多因素逻辑回归模型，以描述嚼食槟榔对心血管疾病风险的影响。
241名（12%）男性和8名（0.7%）女性曾有嚼食槟榔习惯。嚼食槟榔是一般肥胖（比值比[OR]1.43，95%置信区间[CI]1.07-1.91，p=0.017）、中心性肥胖（OR 2.27，95%CI 1.53-3.37，p<0.001）和hs-CRP水平升高（OR 1.38，95%CI 1.03-1.85，p=0.029）的独立危险因素。嚼食槟榔频率更高的受试者收缩压（p=0.025）和baPWV更高（p=0.006）。当前嚼食者的腰围（p=0.015）和腰高比（p=0.022）大于既往嚼食者。
这些发现表明，嚼食槟榔与肥胖以及hs-CRP评估的较高心血管疾病风险相关。此外，还发现停止嚼食槟榔对中心性肥胖有潜在的有益影响。
