Sandhu Sonali, Bansal Yogita, Silakari Om, Bansal Gulshan
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
Bioorg Med Chem. 2014 Aug 1;22(15):3806-14. doi: 10.1016/j.bmc.2014.05.032. Epub 2014 May 22.
Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the researchers to develop novel synthetic and semisynthetic coumarin based therapeutic agents. Many of these agents are hybrid molecules, which are designed through concept of molecular hybridization and have shown multiple pharmacological activities. This multifunctional attribute of these hybrid compounds makes them potential drug candidates for the treatment of multifactorial diseases such as cancer, Alzheimer's disease, metabolic syndromes, AIDS, malaria, and cardiovascular diseases. The present review compiles research reports on development of different coumarin hybrids, classify these on the basis of their therapeutic uses and propose structure-activity relationships. It is intended to help medicinal chemist in designing and synthesizing novel and potent hybrid compounds for the treatment of different disorders.
天然存在的香豆素具有抗氧化、抗炎、抗癌、抑制单胺氧化酶B和抗菌等广泛的活性，研究人员经常使用它们来开发新型的基于香豆素的合成和半合成治疗药物。其中许多药物是杂合分子，它们是通过分子杂交的概念设计出来的，并已显示出多种药理活性。这些杂合化合物的这种多功能特性使它们成为治疗癌症、阿尔茨海默病、代谢综合征、艾滋病、疟疾和心血管疾病等多因素疾病的潜在候选药物。本综述汇编了关于不同香豆素杂合物开发的研究报告，根据它们的治疗用途对其进行分类，并提出构效关系。其目的是帮助药物化学家设计和合成用于治疗不同疾病的新型强效杂合化合物。
