Srikrishna Devulapally, Godugu Chandraiah, Dubey Pramod Kumar
Department of Chemistry, Jawaharlal Nehru Technological University College of Engineering, Kukatpally, Hyderabad 500 085. India.
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500 037. India.
Mini Rev Med Chem. 2018;18(2):113-141. doi: 10.2174/1389557516666160801094919.
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted the attention of chemists and medicinal chemists for decades. Many molecules based on the coumarin ring system have been described utilizing innovative synthetic methods. These synthetic routes have led to interesting analogues of coumarins which possess pharmacological activities like anti-HIV, antimicrobial, antiinflammatory, anticancer, anti-TB, anticonvulsant and MAO inhibitory properties. Details of these studies, correlating structure with biological activity are described in this review.
香豆素（苯并吡喃 -2- 酮或色烯 -2- 酮）环系存在于许多天然产物中，具有多种药理特性。几十年来，它一直吸引着化学家和药物化学家的关注。利用创新的合成方法已描述了许多基于香豆素环系的分子。这些合成路线已产生了有趣的香豆素类似物，它们具有抗艾滋病毒、抗菌、抗炎、抗癌、抗结核、抗惊厥和单胺氧化酶抑制等药理活性。本综述描述了这些研究的细节，即结构与生物活性的相关性。
