肿瘤坏死因子-α rs1800629基因多态性与哮喘风险的关联：一项荟萃分析
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
作者信息
Yang Guangdie, Chen Junjun, Xu Fei, Bao Zhang, Yao Yake, Zhou Jianying
机构信息
Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
出版信息
PLoS One. 2014 Jun 17;9(6):e99962. doi: 10.1371/journal.pone.0099962. eCollection 2014.
OBJECTIVE
The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.
METHODS
We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.
RESULTS
A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI% = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).
CONCLUSIONS
This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.
目的
本研究旨在探讨肿瘤坏死因子-α（TNF-α）基因rs1800629（也称为-308G/A）多态性与哮喘易感性之间的关联。
方法
我们检索了PubMed、Embase、Cochrane对照试验中心注册库（CENTRAL）和万方数据库。采用比值比（OR）及95%置信区间（CI）计算关联强度。
结果
本研究共纳入34项研究，涉及5477例哮喘患者和5962例对照。结果表明，在隐性遗传模型中，TNF-α rs1800629多态性与哮喘风险显著相关（OR = 1.46，95%CI 1.21-1.76，P<0.0001）。亚组分析发现，TNF-α rs1800629多态性在西亚人和南亚人中与哮喘风险显著相关（OR = 2.47，95%CI = 1.48-4.12，P = 0.0005；OR = 1.83，95%CI = 1.42-2.36，P<0.00001），而在东亚人和高加索人中则无此关联。此外，在过敏性哮喘（OR = 1.51，95%CI = 1.24-1.83，P<0.0001）、成人和儿童中（OR = 1.43，95%CI = 1.07-1.91，P = 0.02；OR = 1.57，95%CI = 1.19-2.06，P = 0.001）也观察到显著关联。
结论
这项荟萃分析表明，TNF-α基因的rs1800629多态性是哮喘的一个危险因素。
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