Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510000 Guangdong, China.
Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510000 Guangdong, China.
Biomed Res Int. 2020 Oct 5;2020:5262351. doi: 10.1155/2020/5262351. eCollection 2020.
Several studies have reported conflicting findings regarding the association between tumor necrosis factor-alpha (TNF-) genetic polymorphisms and acute kidney injury (AKI). Therefore, we performed this meta-analysis to further investigate whether TNF- variants are related to AKI susceptibility.
A comprehensive search of observational studies on the association of TNF- polymorphism with AKI susceptibility was conducted in the PubMed, Cochrane, and Embase databases through February 10, 2020. Pooled odds ratios (ORs) and 95% corresponding confidence intervals (95% CIs) were analyzed to evaluate the strength of the relationship.
A total of 8 studies involving 6694 patients (2559 cases and 4135 controls) were included. Pooled analysis showed a trend of increased risk between the TNF- rs1800629 variant and AKI (A vs. G: OR [95%CI] = 1.33 [0.98-1.81]) among the overall population. Ethnicity-stratified analysis indicated that the TNF- rs1800629 variant was a risk factor for Asians (OR [95%CI] = 1.93 [1.59-2.35]) while it is not for Caucasians (OR [95%CI] = 1.04 [0.91-1.20]). Additionally, we also found that TNF- rs1799964 polymorphism was observed to have a significant relationship with AKI risk in Asian patients (C vs. T, OR [95%CI] = 1.26 [1.11-1.43]).
The TNF rs1800629 polymorphism exhibited a trend toward AKI susceptibility with ethnic differences. The relationship was found to be significant among the Asian population, but not among those of Caucasian origin. Additionally, the TNF- rs1799964 polymorphism was also related to a significantly increased risk of AKI in Asians.
多项研究报告称，肿瘤坏死因子-α（TNF-）基因多态性与急性肾损伤（AKI）之间的关联存在矛盾。因此，我们进行了这项荟萃分析，以进一步研究 TNF- 变体是否与 AKI 易感性有关。
通过 2020 年 2 月 10 日在 PubMed、Cochrane 和 Embase 数据库中对 TNF- 多态性与 AKI 易感性相关的观察性研究进行了全面检索。分析汇总优势比（OR）和 95%置信区间（95%CI），以评估关系的强度。
共纳入 8 项研究，共 6694 例患者（2559 例病例和 4135 例对照）。汇总分析显示，TNF- rs1800629 变异与 AKI 之间存在趋势性风险增加（A 对 G：OR [95%CI] = 1.33 [0.98-1.81]）。在亚组分析中，TNF- rs1800629 变异在亚洲人群中是 AKI 的危险因素（OR [95%CI] = 1.93 [1.59-2.35]），但在高加索人群中不是（OR [95%CI] = 1.04 [0.91-1.20]）。此外，我们还发现 TNF- rs1799964 多态性与亚洲患者 AKI 风险之间存在显著关系（C 对 T，OR [95%CI] = 1.26 [1.11-1.43]）。
TNF rs1800629 多态性与 AKI 易感性存在种族差异。这种关系在亚洲人群中显著，而在高加索人群中不显著。此外，TNF- rs1799964 多态性也与亚洲人群 AKI 风险显著增加相关。
