Department of Oral Medicine, School of Stomatology, Wannan Medical College, Wuhu, China.
Department of Hospital Infection Management Office, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, China.
J Periodontal Res. 2021 Apr;56(2):226-235. doi: 10.1111/jre.12820. Epub 2020 Dec 26.
Although the association between tumor necrosis factor-α (TNF-α) G-308A (rs1800629) polymorphism and chronic periodontitis (CP), chronic periodontitis with type 2 diabetes mellitus (DP) is assumed, results of this association have been contradictory. The aim of this study was to assess the relationship between rs1800629 polymorphism and CP/DP susceptibility.
We searched for studies on PubMed, Web of Science, MEDLINE, Chinese National Infrastructure, and WanFang databases. Study selection was performed using specific inclusion and exclusion criteria and fulfilled the PECO (participant, exposure, comparison, and outcome) format. The relationship between rs1800629 polymorphism and CP/DP susceptibility was evaluated by the effect summary odds ratio (OR) and 95% confidence intervals (CIs). Allele, dominant, and recessive genetic models were computed to assess the strength of the association.
A total of 25 case-control studies were included in the analysis. In the Asian population, TNF-α rs1800629 polymorphism was found to be significantly associated with CP in the overall analyses and for all genetic contrasts, while no significant risks were found among Caucasian populations for all genetic contrasts. The TNF-α rs1800629 polymorphism was also associated with increased DP risk in Asians under the fixed-effects model, but not in the recessive comparison.
The meta-analysis suggested that TNF-α rs1800629 polymorphism might affect the risk of CP and DP, particularly in individuals of Asian descent.
虽然肿瘤坏死因子-α（TNF-α）G-308A（rs1800629）多态性与慢性牙周炎（CP）、2 型糖尿病伴慢性牙周炎（DP）之间存在关联，但结果却存在矛盾。本研究旨在评估 rs1800629 多态性与 CP/DP 易感性之间的关系。
我们在 PubMed、Web of Science、MEDLINE、中国国家基础设施和万方数据库中进行了研究。使用特定的纳入和排除标准进行研究选择，并符合 PECO（参与者、暴露、比较和结果）格式。通过效应总结优势比（OR）和 95%置信区间（CI）评估 rs1800629 多态性与 CP/DP 易感性之间的关系。计算等位基因、显性和隐性遗传模型以评估关联的强度。
共有 25 项病例对照研究纳入分析。在亚洲人群中，TNF-α rs1800629 多态性与 CP 在总体分析和所有遗传对比中均存在显著相关性，而在高加索人群中，所有遗传对比均未发现显著风险。TNF-α rs1800629 多态性也与亚洲人群中 DP 风险增加相关，尤其是在固定效应模型下，但在隐性比较中没有。
荟萃分析表明，TNF-α rs1800629 多态性可能影响 CP 和 DP 的风险，尤其是在亚洲血统的个体中。
