Abdou Asmaa Gaber, Elwahed Mohammed Gaber Abd, Serag El-Dien Marwa Mohammed, Eldien Dina Sharaf
Departments of *Pathology and †Dermatology and Andrology, Faculty of Medicine, Menofiya University, Shebein Elkom, Egypt.
Am J Dermatopathol. 2014 Dec;36(12):959-64. doi: 10.1097/DAD.0000000000000114.
Cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represent 45.5% and 37.02%, respectively, of total malignant skin cancer according to the latest registry of Egyptian National Cancer Institute. Minichromosome maintenance (MCM) proteins are essential replication initiation factors. The current study examined the immunohistochemical expression of MCM2 in normal skin (10 cases), some proliferative skin lesions (6 psoriasis, 2 keratoacanthoma, and 2 seborrheic keratosis), and nonmelanoma epithelial skin cancers (20 BCC and 21 SCC). MCM2 was expressed in basal layer of normal epidermis and upregulated in proliferative skin lesions and nonmelanoma epithelial skin cancers without significant differences between the latter groups (P > 0.05). Mean and median values of MCM2 percentage of expression in BCC were higher than that of SCC (P = 0.004). MCM2 promotes proliferative capacity of the cells manifested by its expression in basal layer of epidermis, hyperproliferative skin lesions, and malignant cutaneous tumors. Proliferative capacity of BCC may be higher than SCC and this does not necessarily reflect aggressive behavior.
根据埃及国家癌症研究所的最新登记数据，皮肤基底细胞癌（BCC）和鳞状细胞癌（SCC）分别占皮肤恶性肿瘤总数的45.5%和37.02%。微小染色体维持（MCM）蛋白是重要的复制起始因子。本研究检测了MCM2在正常皮肤（10例）、一些增殖性皮肤病变（6例银屑病、2例角化棘皮瘤和2例脂溢性角化病）以及非黑色素瘤上皮性皮肤癌（20例BCC和21例SCC）中的免疫组化表达。MCM2在正常表皮基底层表达，在增殖性皮肤病变和非黑色素瘤上皮性皮肤癌中上调，后两组之间无显著差异（P>0.05）。BCC中MCM2表达的平均值和中位数高于SCC（P = 0.004）。MCM2通过其在表皮基底层、增殖性皮肤病变和恶性皮肤肿瘤中的表达促进细胞的增殖能力。BCC的增殖能力可能高于SCC，但这不一定反映其侵袭性。
