委内瑞拉梅里达代谢综合征患者的心外膜脂肪组织厚度及其与脂联素的关联。

Epicardial adipose tissue thickness and its association with adiponectin in metabolic syndrome patients from Mérida, Venezuela.

作者信息

Lima-Martínez Marcos M, López-Mendez Gabriel, Odreman Rodolfo, Donis José H, Paoli Mariela

机构信息

Division of Medical Physiology, Department of Physiological Sciences, University of Oriente, Ciudad Bolívar, Venezuela.

Cardiology Research Institute, University Hospital of Los Andes, Mérida, Venezuela.

出版信息

Arq Bras Endocrinol Metabol. 2014 Jun;58(4):352-61. doi: 10.1590/0004-2730000002888.

DOI:10.1590/0004-2730000002888

PMID:24936729

Abstract

OBJECTIVE

To study the relationship between epicardial adipose tissue (EAT) thickness and plasma levels of adiponectin in Venezuelan patients.

SUBJECTS AND METHODS

Thirty-one patients diagnosed with metabolic syndrome (study group) and 27 controls were selected and tested for glycemia, lipids, and adiponectin. EAT thickness, ejection fraction, diastolic function, left ventricular mass (LVM), and left atrial volume (LAV) were determined by transthoracic echocardiography.

RESULTS

EAT thickness was greater in metabolic syndrome patients (5.69 ± 1.12 vs. 3.52 ± 0.80 mm; p = 0.0001), correlating positively with body mass index (BMI) (r = 0.661; p = 0.0001); waist circumference (WC) (r = 0.664; p = 0.0001); systolic (SBP) (r = 0.607; p = 0.0001), and diastolic blood pressure (DBP) (r = 0.447; p = 0.0001); insulin (r = 0.505; p = 0.0001); Tg/HDL-C ratio (r = 0.447; p = 0.0001), non-HDL-C (r = 0.353; p = 0.007); LAV (r = 0.432; p = 0.001), and LVM (r = 0.469; p = 0.0001). EAT thickness correlated negatively with adiponectin (r = -0.499; p = 0.0001).

CONCLUSION

A significant association exists between EAT thickness and both metabolic syndrome components and adiponectin concentration, a link that might be used as a biomarker for this disease.

摘要

目的

研究委内瑞拉患者的心外膜脂肪组织（EAT）厚度与脂联素血浆水平之间的关系。

对象与方法

选取31例诊断为代谢综合征的患者（研究组）和27例对照者，检测其血糖、血脂和脂联素水平。通过经胸超声心动图测定EAT厚度、射血分数、舒张功能、左心室质量（LVM）和左心房容积（LAV）。

结果

代谢综合征患者的EAT厚度更大（5.69±1.12 vs. 3.52±0.80 mm；p = 0.0001），与体重指数（BMI）呈正相关（r = 0.661；p = 0.0001）；腰围（WC）（r = 0.664；p = 0.0001）；收缩压（SBP）（r = 0.607；p = 0.0001）和舒张压（DBP）（r = 0.447；p = 0.0001）；胰岛素（r = 0.505；p = 0.0001）；甘油三酯/高密度脂蛋白胆固醇比值（r = 0.447；p = 0.0001），非高密度脂蛋白胆固醇（r = 0.353；p = 0.007）；LAV（r = 0.432；p = 0.001）和LVM（r = 0.469；p = 0.0001）。EAT厚度与脂联素呈负相关（r = -0.499；p = 0.0001）。