Torres Christopher, Lima-Martínez Marcos M, Rosa Francisco J, Guerra Ernesto, Paoli Mariela, Iacobellis Gianluca, Rodney Marianela, Romero-Vecchione Eduardo, Luisa Saadtjian Maria, Zagala Moisés, Rodney Henry
Laboratorio de Estudios Cardiovasculares y Neurociencias, Departamento de Ciencias Fisiológicas, Escuela de Ciencias de la Salud, Universidad de Oriente, Núcleo Bolívar, Ciudad Bolívar, Venezuela.
Endocrinol Nutr. 2011 Oct;58(8):401-8. doi: 10.1016/j.endonu.2011.06.002. Epub 2011 Aug 6.
To assess the association between epicardial adipose tissue thickness (EAT) and plasma adrenomedullin plasma levels in patients with metabolic syndrome (MS).
Twenty-one patients (12 females and 9 males) with MS according to the International Diabetes Federation guidelines, aged 22-58 years, were enrolled into the study and compared to 19 age-matched control subjects without MS. Plasma glucose, lipid, and adrenomedullin levels were assessed. EAT, left ventricular mass, and carotid intima-media thickness were evaluated by transthoracic two-dimensional echocardiography.
No statistically significant differences were found between the groups in age, sex, and height. Body weight, abdominal circumference (AC), body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were significantly higher (p=0.0001) in MS patients; this group also showed significantly higher glucose (p=0.001), total cholesterol (p=0.01), LDL-C (p=0.03), VLDL-C (p=0.005), triglyceride (p=0.002), Tg/HDL ratio (p=0.0001), and plasma adrenomedullin (3.49±1.21 vs 1.69±0.92 ng/mL; p=0.0001) levels and lower HDL-C (p=0.02) levels as compared to the control group. EAT was significantly thicker in MS patients compared to the control group (8.45±3.14 vs 5.43±0.96; p=0.0001), showed a positive correlation to BMI (r=0.347; p=0.02), AC (r=0.350; p=0.02), DBP (r=0.346; p=0.02), and adrenomedullin levels (r=0.741; p=0.0001). In multiple linear regression analysis, adrenomedullin was the only parameter associated to EAT (R(2)=0.550; p=0.0001).
In this small patient group, a statistically significant association was found between EAT and plasma adrenomedullin levels, which may be considered as a potential biomarker of MS.
评估代谢综合征（MS）患者的心外膜脂肪组织厚度（EAT）与血浆肾上腺髓质素水平之间的关联。
根据国际糖尿病联盟指南，纳入21例年龄在22 - 58岁之间的MS患者（12例女性和9例男性），并与19例年龄匹配的无MS对照受试者进行比较。评估血浆葡萄糖、脂质和肾上腺髓质素水平。通过经胸二维超声心动图评估EAT、左心室质量和颈动脉内膜中层厚度。
两组在年龄、性别和身高方面未发现统计学显著差异。MS患者的体重、腹围（AC）、体重指数（BMI）、收缩压（SBP）和舒张压（DBP）显著更高（p = 0.0001）；与对照组相比，该组还显示出显著更高的血糖（p = 0.001）、总胆固醇（p = 0.01）、低密度脂蛋白胆固醇（LDL - C，p = 0.03）、极低密度脂蛋白胆固醇（VLDL - C，p = 0.005）、甘油三酯（p = 0.002）、甘油三酯/高密度脂蛋白比值（p = 0.0001）和血浆肾上腺髓质素（3.49±1.21 vs 1.69±0.92 ng/mL；p = 0.0001）水平以及更低的高密度脂蛋白胆固醇（HDL - C，p = 0.02）水平。与对照组相比，MS患者的EAT显著更厚（8.45±3.14 vs 5.43±0.96；p = 0.0001），与BMI（r = 0.347；p = 0.02）、AC（r = 0.350；p = 0.02）、DBP（r = 0.346；p = 0.02）和肾上腺髓质素水平（r = 0.741；p = 0.0001）呈正相关。在多元线性回归分析中，肾上腺髓质素是与EAT相关的唯一参数（R² = 0.550；p = 0.0001）。
在这个小患者群体中，发现EAT与血浆肾上腺髓质素水平之间存在统计学显著关联，这可能被视为MS的潜在生物标志物。
