Lima-Martínez Marcos M, Paoli Mariela, Donis José H, Odreman Rodolfo, Torres Christopher, Iacobellis Gianluca
Departamento de Ciencias Fisiológicas, Escuela de Ciencias de la Salud, Universidad de Oriente, Núcleo Bolívar, Ciudad Bolívar, Venezuela.
Endocrinol Nutr. 2013 Dec;60(10):570-6. doi: 10.1016/j.endonu.2013.03.004. Epub 2013 Jun 21.
To define an echocardiographically-assessed cut-off point for epicardial adipose tissue (EAT) thickness associated to metabolic syndrome (MS) components in Venezuelan subjects.
Fifty-two subjects aged 20-65 years diagnosed with MS according to International Diabetes Federation criteria and 45 sex- and age-matched controls were selected. Blood glucose and plasma lipids were tested; EAT thickness and left ventricular mass were measured by echocardiography.
No significant age and sex differences were found between the two groups. Body weight, body mass index, waist circumference, and systolic and diastolic blood pressure were significantly higher (P=.0001) in the MS group. This group showed significantly higher levels of fasting blood glucose (P=.0001), total cholesterol (P=.002), LDL-C (P=.007), non-HDL-C (P=.0001), triglycerides (P=.0001), Tg-HDL-C ratio (P=.0001), and lower HDL-C levels (P=.0001) as compared to the control group. EAT thickness (P=.0001) and left ventricular mass (P=.017) were significantly higher in the MS group. The ROC curve showed an AUC of 0.852 (P=.0001) with a power of the test of 0.99. A 5-mm EAT thickness showed a sensitivity of 84.62% (95%CI: 71.9-93.1) and a specificity of 71.11% (95%CI: 55.7-83.6) for predicting MS. The odds ratio of this population for experiencing MS due to an EAT ≥ 5 mm was 8.25 (95%CI: 3.15-21.56; P=.0001).
An EAT value ≥ 5 mm has good sensitivity and specificity for predicting MS in the Venezuelan population.
确定经超声心动图评估的、与委内瑞拉人群代谢综合征（MS）各组分相关的心外膜脂肪组织（EAT）厚度的切点。
选取52名年龄在20 - 65岁之间、根据国际糖尿病联盟标准诊断为MS的受试者以及45名年龄和性别匹配的对照组。检测血糖和血脂；通过超声心动图测量EAT厚度和左心室质量。
两组之间未发现显著的年龄和性别差异。MS组的体重、体重指数、腰围以及收缩压和舒张压显著更高（P = 0.0001）。与对照组相比，该组的空腹血糖（P = 0.0001）、总胆固醇（P = 0.002）、低密度脂蛋白胆固醇（P = 0.007）、非高密度脂蛋白胆固醇（P = 0.0001）、甘油三酯（P = 0.0001）、甘油三酯 - 高密度脂蛋白胆固醇比值（P = 0.0001）水平显著更高，而高密度脂蛋白胆固醇水平更低（P = 0.0001）。MS组的EAT厚度（P = 0.0001）和左心室质量（P = 0.017）显著更高。ROC曲线显示曲线下面积（AUC）为0.852（P = 0.0001），检验效能为0.99。EAT厚度为5mm时，预测MS的敏感性为84.62%（95%CI：71.9 - 93.1），特异性为71.11%（95%CI：55.7 - 83.6）。该人群中EAT≥5mm导致发生MS的比值比为8.25（95%CI：3.15 - 21.56；P = 0.0001）。
EAT值≥5mm对预测委内瑞拉人群的MS具有良好的敏感性和特异性。
