有无心肌梗死患者中超敏C反应蛋白、糖尿病与牙周病之间的关系。
Relation between ultra-sensitive C-reactive protein, diabetes and periodontal disease in patients with and without myocardial infarction.
作者信息
Arregoces Francina Escobar, Uriza Catalina Latorre, Porras Juliana Velosa, Camargo Maria Beatriz Ferro, Morales Alvaro Ruiz
机构信息
Periodontal Department, School of Dentistry, Pontificia Universidad Javeriana and Fundación Cardio Infantil, Bogotá, Colombia.
Periodontal Department, School of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia.
出版信息
Arq Bras Endocrinol Metabol. 2014 Jun;58(4):362-8. doi: 10.1590/0004-2730000002899.
OBJECTIVE
The purpose of this study was to evaluate the impact of diabetes and periodontal disease in us-CRP, an inflammatory marker in patients with and without acute myocardial infarction (AMI).
SUBJECTS AND METHODS
A case-control study was conducted in 401 subjects aged between 30 and 75 years, living in Bogotá D.C. (Colombia). Patients arriving at the emergency room of the San Ignacio University Hospital with AMI were included into the case group. The control group was defined as those subjects without AMI. The following blood tests were performed: complete blood count (CBC), glycemia, total cholesterol, triglycerides, cHDL, cLDL, and us-CRP. Patients with infections or antibiotic treatment within the last three months, who had received periodontal treatment within the six months prior to the study entry, had oral ulcerations, or less than seven teeth were excluded from the study. Periodontal disease was diagnosed based on the 1999 Armitage's classification.
RESULTS
The mean us-CRP value found in diabetic patients with severe chronic periodontitis was 5.31 mg/L (SD 6.82), and 2.38 mg/L (SD 4.42) in non-diabetic patients, being statistically significant (p = 0.000).
CONCLUSION
Diabetes had an impact in periodontal disease and us-CRP. In patients with AMI, DM and PD considerably increased the us-CRP.
目的
本研究旨在评估糖尿病和牙周疾病对超敏C反应蛋白（us-CRP）的影响，us-CRP是急性心肌梗死（AMI）患者和非急性心肌梗死患者体内的一种炎症标志物。
受试者与方法
在居住于哥伦比亚首都波哥大的401名年龄在30至75岁之间的受试者中开展了一项病例对照研究。因AMI前往圣伊格纳西奥大学医院急诊室就诊的患者被纳入病例组。对照组定义为无AMI的受试者。进行了以下血液检测：全血细胞计数（CBC）、血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇（cHDL）、低密度脂蛋白胆固醇（cLDL）和超敏C反应蛋白（us-CRP）。过去三个月内有感染或接受抗生素治疗、在研究入组前六个月内接受过牙周治疗、有口腔溃疡或牙齿少于七颗的患者被排除在研究之外。牙周疾病根据1999年阿米蒂奇分类法进行诊断。
结果
重度慢性牙周炎糖尿病患者的平均超敏C反应蛋白（us-CRP）值为5.31mg/L（标准差6.82），非糖尿病患者为2.38mg/L（标准差4.42），差异具有统计学意义（p = 0.000）。
结论
糖尿病对牙周疾病和超敏C反应蛋白（us-CRP）有影响。在AMI患者中，糖尿病和牙周疾病显著增加了超敏C反应蛋白（us-CRP）水平。
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