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体育锻炼对围绝经期妇女健康相关生活质量和血脂的影响：一项随机安慰剂对照试验

Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: a randomized placebo-controlled trial.

作者信息

Zhang Jing, Chen Guiping, Lu Weiwei, Yan Xiaoyan, Zhu Sainan, Dai Yue, Xi Sisi, Yao Chen, Bai Wenpei

机构信息

From the 1Department of Gynecology, The First Hospital of Peking University, Beijing, China; 2The Union of The First Hospital of Peking University, Beijing, China; 3The Peking University Clinical Research Institute, Beijing, China; and 4Department of Medical Statistics, The First Hospital of Peking University, Beijing, China.

出版信息

Menopause. 2014 Dec;21(12):1269-76. doi: 10.1097/GME.0000000000000264.

DOI:10.1097/GME.0000000000000264

PMID:24937024

Abstract

OBJECTIVE

This study aims to evaluate the treatment effects of physical exercise on menopausal symptoms in middle-aged female medical staff experiencing perimenopausal syndrome.

METHODS

A total of 157 female medical staff aged 40 to 55 years and with a Kupperman index score of 15 points or higher were randomized 1:1 into an intervention group (n = 78) or a control group (n = 79). Women in the intervention group were asked to perform aerobic physical exercise (walking with strides) three times a week or more, whereas those in the control group continued as normal. Measurements were taken at baseline and on weeks 4, 8, and 12, with total Kupperman index score, scores on individual elements of the scale, weight, and waist circumference recorded. In addition, fasting blood glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were recorded at baseline and on week 12. The effects of physical exercise therapy on perimenopausal syndrome were evaluated by comparing changes in these parameters between the control group and the intervention group.

RESULTS

Fifty-four and 57 women completed all three follow-ups in the intervention and control groups, respectively. On week 12, the mean (SD) change in total Kupperman index score (-9.23 [6.23]) from baseline to week 12; the mean (SD) changes in individual scores for paresthesia (-1.08 [1.51]), insomnia (-1.00 [1.46]), irritability (-1.00 [1.34]), joint or muscle pain (-0.75 [0.74]), fatigue (-0.56 [0.75]), headache (-0.54 [0.75]), formication (-0.38 [0.66]), and sexual life (-0.62 [1.71]); and the mean (SD) changes in total cholesterol (-0.76 [0.63] mmol/L) and triglycerides (-0.20 [0.50] mmol/L) were significantly higher in the intervention group than in the control group (P < 0.05). In the intervention group, total Kupperman index score, weight, body mass index, waist circumference, triglycerides, and total cholesterol were significantly lower on week 12 compared with baseline (P < 0.05).

CONCLUSIONS

Physical exercise can substantially reduce menopausal symptoms and improve blood lipid status and body weight.

摘要

目的

本研究旨在评估体育锻炼对患有围绝经期综合征的中年女性医护人员更年期症状的治疗效果。

方法

总共157名年龄在40至55岁之间、库珀曼指数得分在15分及以上的女性医护人员被按1:1随机分为干预组（n = 78）或对照组（n = 79）。干预组的女性被要求每周进行三次或更多次有氧体育锻炼（大步走），而对照组的女性则照常生活。在基线期以及第4、8和12周进行测量，记录库珀曼指数总分、量表各单项得分、体重和腰围。此外，在基线期和第12周记录空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇。通过比较对照组和干预组这些参数的变化来评估体育锻炼疗法对围绝经期综合征的影响。

结果

干预组和对照组分别有54名和57名女性完成了所有三次随访。在第12周时，干预组从基线到第12周库珀曼指数总分的平均（标准差）变化为（-9.23 [6.23]）；感觉异常单项得分的平均（标准差）变化为（-1.08 [1.51]）、失眠为（-1.00 [1.46]）、易怒为（-1.00 [1.34]）、关节或肌肉疼痛为（-0.75 [0.74]）、疲劳为（-0.56 [0.75]）、头痛为（-0.54 [0.75]）、蚁走感为（-0.38 [0.66]）以及性生活为（-0.62 [1.71]）；总胆固醇的平均（标准差）变化为（-0.76 [0.63] mmol/L），甘油三酯的平均（标准差）变化为（-0.20 [0.50] mmol/L），干预组均显著高于对照组（P < 0.05）。在干预组中，与基线相比，第12周时库珀曼指数总分、体重、体重指数、腰围、甘油三酯和总胆固醇均显著降低（P < 0.05）。