Castillo Saavedra Laura, Morales-Quezada Leon, Doruk Deniz, Rozinsky Joanna, Coutinho Livia, Faria Paula, Perissinotti Iago, Wang Qing-Mei, Fregni Felipe
Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA.
Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA; School of Health Sciences, De Montfort University, Leicester, UK.
Neurosci Lett. 2014 Aug 8;577:61-5. doi: 10.1016/j.neulet.2014.06.021. Epub 2014 Jun 14.
Transcranial pulsed current stimulation (tPCS) is a non-invasive brain stimulation technique that employs weak, pulsed current at different frequency ranges, inducing electrical currents that reach cortical and subcortical structures. Very little is known about its effects on brain oscillations and functional connectivity and whether these effects are dependent on the frequency of stimulation. Our aim was to evaluate the effects of tPCS with different frequency ranges in cortical oscillations indexed by high-resolution qEEG changes for power and interhemispheric coherence. Thirty-eight healthy subjects were enrolled and received a single 20-min session of either sham or active stimulation with 1 Hz, 100 Hz or random frequency (1-5 Hz). We conducted an exploratory analysis to detect changes in mean power for theta, alpha and beta, and interhemispheric coherence for alpha and theta and four different sub-bands cognitive and non-specific adverse effects were recorded. We found that active stimulation with a random frequency ranging between 1 and 5 Hz is able to significantly increase functional connectivity for the theta and low-alpha band as compared to sham and active stimulation with either 1 or 100 Hz. Based on these findings, we discuss the possible effects of tPCS on resting functional connectivity for low-frequency bands in fronto-temporal areas. Future studies should be conducted to investigate the potential benefit of these induced changes in pathologic states.
经颅脉冲电流刺激（tPCS）是一种非侵入性脑刺激技术，它在不同频率范围内使用微弱的脉冲电流，诱导电流到达皮质和皮质下结构。关于其对脑振荡和功能连接的影响以及这些影响是否依赖于刺激频率，人们了解甚少。我们的目的是通过高分辨率定量脑电图（qEEG）功率和半球间相干性变化所索引的皮质振荡，评估不同频率范围的tPCS的影响。招募了38名健康受试者，他们接受了单次20分钟的假刺激或1赫兹、100赫兹或随机频率（1 - 5赫兹）的主动刺激。我们进行了探索性分析，以检测θ波、α波和β波的平均功率变化，以及α波和θ波的半球间相干性变化，并记录了四种不同子频段的认知和非特异性不良反应。我们发现，与假刺激以及1赫兹或100赫兹的主动刺激相比，1至5赫兹的随机频率主动刺激能够显著增加θ波和低α波段的功能连接。基于这些发现，我们讨论了tPCS对额颞叶区域低频带静息功能连接的可能影响。未来应开展研究，以调查这些诱导变化在病理状态下的潜在益处。
