Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN 46202, USA.
Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN 46202, USA.
Cancer Cell. 2014 Jun 16;25(6):711-2. doi: 10.1016/j.ccr.2014.05.026.
Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that responds to checkpoint blockade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.
胰腺癌的促结缔组织增生被认为是具有侵袭性的生物学特征。在本期《癌细胞》杂志中，Özdemir 及其同事以及 Rhim 及其同事表明，靶向基质会导致未分化的侵袭性胰腺癌对检查点阻断或抗血管生成治疗产生反应，揭示了基质在这种癌症中的保护作用。
