Psychiatric Hospital, University of Munich, Germany.
Int J Psychiatry Clin Pract. 2005;9(3):168-74. doi: 10.1080/13651500510029237.
Recent studies indicate that individuals with schizophrenia have a two-fold incidence of traffic accidents. Cognitive and psychomotor impairment as a core feature of schizophrenia and the effects of neuroleptic treatment play an essential role in this respect. Few experimental studies have been conducted so far looking at the effects of neuroleptics on driving ability in schizophrenia. Controlled, randomised trials are totally missing. The limited database indicates that most schizophrenic patients show significant impairment in cognitive functions relevant for driving ability compared to healthy controls. There is some but limited evidence that patients under novel atypical neuroleptics show less impairment compared to conventional neuroleptics. More clinical and experimental studies are warranted.
最近的研究表明，精神分裂症患者发生交通事故的几率是一般人的两倍。认知和运动障碍是精神分裂症的核心特征，而抗精神病药物治疗的效果在这方面起着重要作用。迄今为止，很少有实验研究关注抗精神病药物对精神分裂症患者驾驶能力的影响。完全缺乏对照、随机的试验。有限的数据库表明，与健康对照组相比，大多数精神分裂症患者在与驾驶能力相关的认知功能方面表现出显著的损害。有一些但有限的证据表明，新型非典型抗精神病药物治疗的患者比传统抗精神病药物治疗的患者损害程度较轻。需要更多的临床和实验研究。
