Tarocco Anna, Ballardini Elisa, Garani Giampaolo
Department of Medical Sciences, Pediatric Section, S. Anna University Hospital, Ferrara, Italy.
Department of Medical Sciences, Neonatology and NICU, S. Anna University Hospital, Ferrara, Italy.
Pediatr Neurol. 2014 Jul;51(1):154-6. doi: 10.1016/j.pediatrneurol.2014.03.006. Epub 2014 Mar 15.
Brain malformations represent a major cause of refractory seizures. Standardized protocols to treat status epilepticus of newborn are not available in the literature.
We present a case report of use of ketamine administered to a late preterm with Pierre Robin sequence, lissencephaly, polymicrogyria, and severe epilepsy.
The infusion of ketamine permitted resolution of status epilepticus, cardiorespiratory stabilization, and improved parental care for 15 days. No significant side effects were noted.
In the literature there are few studies regarding the use of ketamine for refractory status epilepticus, and only in nine of these described the use of, ketamine in children (2 months-18 years). This is the first report to document the effective use of ketamine in the newborn with status epilepticus.
脑畸形是难治性癫痫发作的主要原因。文献中尚无治疗新生儿癫痫持续状态的标准化方案。
我们报告一例对晚期早产儿使用氯胺酮的病例，该患儿患有皮埃尔·罗宾序列征、无脑回畸形、多小脑回畸形和严重癫痫。
输注氯胺酮使癫痫持续状态得到缓解，心肺功能稳定，并改善了15天的家长护理情况。未观察到明显副作用。
文献中关于氯胺酮用于难治性癫痫持续状态的研究很少，其中仅有9项描述了氯胺酮在儿童（2个月至18岁）中的使用。这是第一份记录氯胺酮有效用于新生儿癫痫持续状态的报告。
