Zhang WenCheng, Liu Jinbo, Wang Guangshun
Department of Oncology, Bao Di Hospital, Bao Di Clinical College, Tianjin Medical University, Guang Chuan Road, Bao Di, Tian Jin, People's Republic of China.
Tumour Biol. 2014 Jul;35(7):6235-44. doi: 10.1007/s13277-014-2202-8. Epub 2014 Jun 18.
Over the past decade, microRNAs (miRNAs) have become a new paradigm of gene regulation. miRNAs are involved in a wide array of carcinogenic processes. Indeed, increasing evidence has shown the importance of miRNAs in cancer, suggesting their possible use as diagnostic, predictive and prognostic biomarkers, leading to miRNA-based anti-cancer therapies, either alone or in combination with current targeted therapies, with the goal of improving cancer treatment responses and increasing cure rates. The advantage of using a miRNA approach is based on the ability to concurrently target multiple effectors of pathways involved in cell proliferation, migration and survival. This review sheds new light on miRNA regulation of genes that play critical roles in the process of malignant transformation and tumour metastasis, the dysregulation of miRNA expression in cancer development and the development of miRNA-based diagnostics and therapeutics.
在过去十年中，微小RNA（miRNA）已成为基因调控的一种新范式。miRNA参与了广泛的致癌过程。事实上，越来越多的证据表明miRNA在癌症中具有重要作用，这表明它们有可能用作诊断、预测和预后生物标志物，从而产生基于miRNA的抗癌疗法，单独使用或与当前的靶向疗法联合使用，目的是改善癌症治疗反应并提高治愈率。使用miRNA方法的优势基于其能够同时靶向参与细胞增殖、迁移和存活的多个信号通路效应器。本文综述为在恶性转化和肿瘤转移过程中起关键作用的基因的miRNA调控、癌症发展中miRNA表达的失调以及基于miRNA的诊断和治疗方法的发展提供了新的见解。
