Department of Clinical & Translational Research, University of Rochester Medical Center, Rochester, NY, USA.
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Function (Oxf). 2021 Apr 23;2(3):zqab022. doi: 10.1093/function/zqab022. eCollection 2021.
Epigenetic alterations, including DNA methylation, microRNA, and long noncoding RNA, play important roles in the pathogenesis of numerous respiratory health conditions and diseases. Exposure to tobacco smoking has been found to be associated with epigenetic changes in the respiratory tract. Marketed as a less harmful alternative to combustible cigarettes, electronic cigarette (e-cigarette) has rapidly gained popularity in recent years, especially among youth and young adults. Accumulative evidence from both animal and human studies has shown that e-cigarette use (vaping) is also linked to similar respiratory health conditions as observed with cigarette smoking, including wheezing, asthma, and COPD. This review aims to provide an overview of current studies on associations of smoking and vaping with epigenetic alterations in respiratory cells and provide future research directions in epigenetic studies related to vaping.
表观遗传改变，包括 DNA 甲基化、microRNA 和长链非编码 RNA，在许多呼吸健康状况和疾病的发病机制中发挥重要作用。研究发现，吸烟会导致呼吸道的表观遗传改变。电子烟作为可燃香烟的一种危害较小的替代品，近年来迅速普及，尤其在青少年和年轻人中更为流行。来自动物和人体研究的累积证据表明，电子烟的使用（蒸气吸入）也与吸烟观察到的类似呼吸健康状况有关，包括喘息、哮喘和 COPD。本综述旨在概述目前关于吸烟和蒸气吸入与呼吸细胞表观遗传改变相关的研究，并为与蒸气吸入相关的表观遗传研究提供未来的研究方向。
