Renaud Justine, Martinoli Maria-Grazia
Department of Medical Biology, C.P. 500, U.Q.T.R., Trois-Rivières, Qc., G9A 5H7, Canada.
Curr Pharm Biotechnol. 2014;15(4):318-29. doi: 10.2174/1389201015666140617101332.
Under normal conditions, most of the central nervous system (CNS) is protected by the blood brain barrier (BBB) from systemic inflammation progression and from the infiltration of immune cells. As a consequence, the CNS developed an original way to provide surveillance, defense and repair, which relies on the complex process of neuroinflammation. Despite tight regulation, neuroinflammation is frequently the cause of irreversible nerve cell loss but it is also where the solution lies. Specific immune crosstalk taking place in the CNS needs to be decoded in order to identify the best therapeutic strategies aimed at helping the CNS restore homeostasis in difficult conditions such as in neurodegenerative disorders. This review deals with the double-edged sword nature of neuroinflammation and the use of resveratrol in various models as one of the most promising therapeutic molecules for preventing the consequences of nerve cell autodestruction.
在正常情况下，中枢神经系统（CNS）的大部分受到血脑屏障（BBB）的保护，免受全身炎症进展和免疫细胞浸润的影响。因此，中枢神经系统形成了一种独特的方式来进行监测、防御和修复，这依赖于神经炎症的复杂过程。尽管有严格的调控，但神经炎症常常是不可逆神经细胞损失的原因，但它也是解决问题的关键所在。为了确定在诸如神经退行性疾病等困难情况下帮助中枢神经系统恢复内稳态的最佳治疗策略，需要解读中枢神经系统中发生的特定免疫串扰。本综述探讨了神经炎症的双刃剑性质，以及白藜芦醇在各种模型中作为预防神经细胞自毁后果最有前景的治疗分子之一的应用。
