Gao Huile, Zhang Qianyu, Yu Zhiqiang, He Qin
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.
Curr Pharm Biotechnol. 2014;15(3):210-9. doi: 10.2174/1389201015666140617092552.
Liposomes are widely used as drug delivery systems and several liposome-based nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have been decorated onto nanoparticulated vesicle such as liposomes to further improve the intracellular delivery efficiency. However, the poor selectivity of CPPs hindered their application, especially in the in vivo application. To resolve this issue, several strategies have been developed, including shielding and environment-triggered deshielding of CPPs as well as designing of environment-responsive CPPs and specific- targeting CPPs and last but not least, combination strategy. In this review, the abovementioned strategies were discussed.
脂质体作为药物递送系统被广泛应用，并且几种基于脂质体的纳米药物已被批准用于临床。细胞穿透肽（CPPs）已被修饰到纳米颗粒囊泡（如脂质体）上，以进一步提高细胞内递送效率。然而，CPPs的选择性较差阻碍了它们的应用，尤其是在体内应用中。为了解决这个问题，已经开发了几种策略，包括CPPs的屏蔽和环境触发去屏蔽，以及设计环境响应性CPPs和特异性靶向CPPs，最后但同样重要的是，联合策略。在这篇综述中，对上述策略进行了讨论。
