使用RNAstructure软件包预测保守的RNA结构。
Using the RNAstructure Software Package to Predict Conserved RNA Structures.
作者信息
Mathews David H
机构信息
Department of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York.
出版信息
Curr Protoc Bioinformatics. 2014 Jun 17;46:12.4.1-12.4.22. doi: 10.1002/0471250953.bi1204s46.
Abstract
The structures of many non-coding RNA (ncRNA) are conserved by evolution to a greater extent than their sequences. By predicting the conserved structure of two or more homologous sequences, the accuracy of secondary structure prediction can be improved as compared to structure prediction for a single sequence. This unit provides protocols for the use of four programs in the RNAstructure suite for prediction of conserved structures, Multilign, TurboFold, Dynalign, and PARTS. These programs can be run via Web servers, on the command line, or with graphical interfaces.
摘要
许多非编码RNA（ncRNA）的结构在进化过程中比其序列具有更高的保守性。通过预测两个或多个同源序列的保守结构，与单个序列的结构预测相比，二级结构预测的准确性可以得到提高。本单元提供了RNAstructure套件中四个程序用于预测保守结构的协议，即Multilign、TurboFold、Dynalign和PARTS。这些程序可以通过网络服务器、命令行或图形界面运行。
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