Motallebnejad Mina, Abedi Seyed Mohammad, Seyedmajidi M, Moghadamnia A A, Ashrafpour M, Salehi M, Moslemi D, Ghorbani A
Associate Professor, Department of Oral and Maxillofacial, Dental Material Research Center, Dental School, Babol University of Medical Sciences Babol, Iran.
Assistant Professor, Department of Radiology, Nuclear Medicine, Faculty of Medicine Mazandaran University of Medical Sciences, Sari, Iran.
J Contemp Dent Pract. 2014 Jan 1;15(1):8-11. doi: 10.5005/jp-journals-10024-1479.
One of the most significant side effects of radiotherapy for head and neck cancers is xerostomia as a result of salivary gland damage. Considering pharmaco- logical effects of propolis, we evaluated its protective effect on salivary glands subjected to radiotherapy of head and neck cancer patients.
Twenty-one male albino rats (8-11 W, 190 ± 5 gm) were divided into three groups of seven animals. Scintigraphy was performed in all the groups. Then groups 1 (S) and 2 (SR) received normal saline injections and group 3 (PR) received propolis injection over 3 days. After that groups 2 and 3 were exposed to gamma radiation and all the rats underwent scintigraphic assessment on third day and 70th day after irradiation. The lips and tongues of rats in groups 2 and 3 were examined for mucositis daily in first 10 days. At the end, the parotid glands of all rats were examined histologically.
Scintigraphy results of third and 70th day after irradiation showed statistically significant differences between PR and SR as well as SR and S. However, there was no significant difference between the PR and S groups. Histopathologic assessment demonstrated significant difference between SR, PR and S.
These results suggest that propolis has protective effects on salivary gland function in animal models whilst it did not prevent radiation-induced histologic changes in tissues. Further investigations are needed to elucidate mechanisms of propolis actions. Clinical significance: Regarding to the results of this study, propolis may be useful in reduction xerostomia due to radiation to salivary glands and may be helpful for head and neck cancer patients.
头颈部癌症放疗最显著的副作用之一是唾液腺损伤导致的口干症。考虑到蜂胶的药理作用，我们评估了其对接受头颈部癌症放疗患者唾液腺的保护作用。
21只雄性白化大鼠（8 - 11周龄，体重190 ± 5克）被分为三组，每组7只。对所有组进行了闪烁扫描。然后，第1组（S组）和第2组（SR组）注射生理盐水，第3组（PR组）在3天内注射蜂胶。之后，第2组和第3组接受伽马辐射，所有大鼠在照射后第3天和第70天接受闪烁扫描评估。在最初的10天里，每天检查第2组和第3组大鼠的嘴唇和舌头是否有粘膜炎。最后，对所有大鼠的腮腺进行组织学检查。
照射后第3天和第70天的闪烁扫描结果显示，PR组与SR组以及SR组与S组之间存在统计学显著差异。然而，PR组和S组之间没有显著差异。组织病理学评估显示SR组、PR组和S组之间存在显著差异。
这些结果表明，蜂胶对动物模型中的唾液腺功能具有保护作用，同时它并不能预防辐射引起的组织学变化。需要进一步研究以阐明蜂胶作用的机制。临床意义：根据本研究结果，蜂胶可能有助于减少因唾液腺辐射导致的口干症，对头颈部癌症患者可能有帮助。
