Aghel Sara, Pouramir Mahdi, Moghadamnia Ali Akbar, Moslemi Dariush, Molania Tahere, Ghassemi Leila, Motallebnejad Mina
Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Professor, Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran.
J Dent Res Dent Clin Dent Prospects. 2014 Fall;8(4):235-9. doi: 10.5681/joddd.2014.042. Epub 2014 Dec 3.
Background and aims. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva containsantioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism iscompromised with oxidative stress produced by radiation therapy. Therefore, the aim of the present study was to investigatethe effect of propolis on salivary total antioxidant capacity in irradiated rats. Materials and methods. The study was conducted on 28 rats, 7-11 weeks of age (160±20 g), divided into four groups:saline with no radiation (S), saline and radiation (SR), propolis with no radiation (P) [400 mg/kg IP], propolis and radiation(PR) [400 mg/kg IP]. SP and PR were exposed to 15 Gy of gamma irradiation for 7 minutes and 39 seconds. The rats received intraperitoneal injections each day for 10 days, and their tongues and lips were daily examined for mucositis; salivasample were also taken three times on days 0, 6, and 10. Results. Mucositis incidence appeared to be delayed in the PR compared to the SR, and the severity was significantlyhigher in the SR compared to the PR. No significant alterations were observed in salivary antioxidant levels during the ex-periment, except the SR group in which a significant reduction was found. Conclusion. Propolis might reduce and delay radiation-induced mucositis in animal models; it might be able to prevent thereduction in salivary antioxidant levels in irradiated rats as well.
背景与目的。研究了蜂胶的抗氧化和抗炎特性。由于唾液中含有抗氧化剂，而头颈部放疗主要影响唾液，放疗产生的氧化应激会损害唾液抗氧化防御机制。因此，本研究的目的是调查蜂胶对受辐照大鼠唾液总抗氧化能力的影响。材料与方法。本研究以28只7 - 11周龄（160±20克）的大鼠为对象，分为四组：未接受辐射的生理盐水组（S）、接受辐射的生理盐水组（SR）、未接受辐射的蜂胶组（P）[腹腔注射400毫克/千克]、接受辐射的蜂胶组（PR）[腹腔注射400毫克/千克]。SP组和PR组接受15戈瑞的γ射线照射7分39秒。大鼠每天接受腹腔注射，持续10天，每天检查其舌头和嘴唇是否出现粘膜炎；在第0天、第6天和第10天还采集三次唾液样本。结果。与SR组相比，PR组粘膜炎发病率似乎有所延迟，且与PR组相比，SR组的严重程度明显更高。在实验期间，除SR组唾液抗氧化水平显著降低外，未观察到唾液抗氧化水平有显著变化。结论。蜂胶可能减轻和延缓动物模型中辐射诱导的粘膜炎；它也可能能够防止受辐照大鼠唾液抗氧化水平的降低。
