Park Mi Sung, Han Kwang-Hyub, Kim Seung Up
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Expert Rev Gastroenterol Hepatol. 2014 Jul;8(5):501-11. doi: 10.1586/17474124.2014.898563. Epub 2014 Mar 20.
Prognosis of patients with chronic liver disease is determined by the extent and progression of liver fibrosis, which may ultimately lead to hepatocellular carcinoma (HCC). Liver biopsy (LB) is regarded as the gold standard to estimate the extent of liver fibrosis. However, because LB has several limitations, the foremost being its invasiveness, several non-invasive methods for assessing liver fibrosis have been proposed. Of these, transient elastography (TE) provides an accurate representation of the extent of liver fibrosis. Furthermore, recent studies have focused on the usefulness of TE for assessing the risk of HCC development and HCC recurrence after curative treatment, and developed novel models to calculate the risk of HCC development based on TE findings. These issues are discussed in this expert review.
慢性肝病患者的预后取决于肝纤维化的程度和进展情况，而肝纤维化最终可能会导致肝细胞癌（HCC）。肝活检（LB）被视为评估肝纤维化程度的金标准。然而，由于肝活检存在若干局限性，其中最主要的是其侵入性，因此人们提出了几种非侵入性的肝纤维化评估方法。其中，瞬时弹性成像（TE）能准确反映肝纤维化的程度。此外，最近的研究聚焦于瞬时弹性成像在评估肝细胞癌发生风险以及根治性治疗后肝细胞癌复发风险方面的作用，并基于瞬时弹性成像的结果开发了新的模型来计算肝细胞癌发生的风险。本专家综述将对这些问题进行讨论。
