Atta Ajax Mercês, Oliveira Rodrigo C, Oliveira Isabela S, Menezes Mariana P, Santos Taciana P S, Sousa Atta Maria Luiza B, Santiago Mittermayer B
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Rheumatol Int. 2015 Jan;35(1):167-70. doi: 10.1007/s00296-014-3069-0. Epub 2014 Jun 18.
Jaccoud's arthropathy (JA) is a condition characterized clinically by 'reversible' joint deformities along with an absence of articular erosions on a plain radiograph. The main clinical entity associated with JA is systemic lupus erythematosus (SLE) with a prevalence of around 5 %. The aim of the present study was to compare the inflammatory markers including cytokine levels in blood of SLE patients with and without JA. Patients with diagnosis of SLE as defined by ACR criteria were screened and divided in two groups, one with JA and one control group without JA. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complement C3 and C4 levels antinuclear antibodies (ANA), anti-dsDNA antibodies and serum levels of IL-2, IL-6, IL-10, IL-21, IL-22 and TNF-α were determined in all patients. Eighty female patients with SLE, 18 (22.5 %) with JA and 62 (77.5 %) without JA, were included in this study. JA patients had higher disease duration (p = 0.008), ESR (p < 0.001), CRP level (p = 0.002), ANA titer (p < 0.001) and dsDNA antibody level (p = 0.009). The serum levels of IL-2, IL-10, IL-21, IL-22 and TNF-α were not significantly different between the two groups (p > 0.05), but the level of IL-6 was higher in JA group (p < 0.001). The serum level of IL-6 might have a correlation with JA secondary to SLE.
雅库病（JA）是一种临床上以“可逆性”关节畸形为特征且X线平片上无关节侵蚀的疾病。与JA相关的主要临床病症是系统性红斑狼疮（SLE），患病率约为5%。本研究的目的是比较有和没有JA的SLE患者血液中的炎症标志物，包括细胞因子水平。根据美国风湿病学会（ACR）标准诊断为SLE的患者接受筛查并分为两组，一组有JA，一组为无JA的对照组。测定了所有患者的红细胞沉降率（ESR）、C反应蛋白（CRP）、补体C3和C4水平、抗核抗体（ANA）、抗双链DNA抗体以及IL-2、IL-6、IL-10、IL-21、IL-22和TNF-α的血清水平。本研究纳入了80例SLE女性患者，其中18例（22.5%）有JA，62例（77.5%）无JA。JA患者的病程更长（p = 0.008）、ESR更高（p < 0.001）、CRP水平更高（p = 0.002）、ANA滴度更高（p < 0.001）以及双链DNA抗体水平更高（p = 0.009）。两组之间IL-2、IL-10、IL-21、IL-22和TNF-α的血清水平无显著差异（p > 0.05），但JA组的IL-6水平更高（p < 0.001）。IL-6的血清水平可能与SLE继发的JA相关。
