维生素D摄入量与2型糖尿病风险：前瞻性队列研究的荟萃分析
Vitamin D intake and type 2 diabetes risk: a meta-analysis of prospective cohort studies.
作者信息
Zhao Li-min, Tian Xiao-qin, Ge Jia-pu, Xu Yan-cheng
机构信息
Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, HuBei 430071, P.R. China.
Department of Endocrinology, Traditional Chinese Medicine Hospital, XinJiang Medical University, Urumqi, XinJiang 830000, P.R. China.
出版信息
Afr Health Sci. 2013 Dec;13(4):1130-8. doi: 10.4314/ahs.v13i4.38.
BACKGROUND
The findings form studies on the relationship between vitamin D and type 2 diabetes were inconsistent.
OBJECTIVES
To elucidate the association between vitamin D consumption and type 2 diabetes risk by conducting a meta-analysis.
METHODS
We conducted a systematic literature search to identify prospective cohort studies of vitamin D intake and type 2 diabetes risk prior to November 2012. Eligible studies were retrieved via both computer searches and manual review of references. The summary risk estimates were calculated based on the highest versus the lowest categories.
RESULTS
Meta-analysis of 4 prospective cohort studies involving 187, 592 participants and 9, 456 incident cases showed an absence of significant association between total vitamin D intake and type 2 diabetes risk. The combined RR was 0.93 (95% CI: 0.85-1.01). The associations were similar for subgroup analyses, a combined RR respectively was 0.94 (95% CI: 0.77-1.08), 0.91 (95% CI: 0.77-1.08), 0.93 (95% CI: 0.84-1.02), and 0.92 (95% CI: 0.84-1.01) for the intake of dietary vitamin D, supplemental vitamin D, total vitamin D in USA and total vitamin D for women only.
CONCLUSIONS
Our results support that there was no association between vitamin D intake and type 2 diabetes.
背景
关于维生素D与2型糖尿病之间关系的研究结果并不一致。
目的
通过进行一项荟萃分析来阐明维生素D摄入量与2型糖尿病风险之间的关联。
方法
我们进行了一项系统的文献检索，以确定2012年11月之前关于维生素D摄入量与2型糖尿病风险的前瞻性队列研究。通过计算机检索和参考文献的人工审查来检索符合条件的研究。根据最高类别与最低类别计算汇总风险估计值。
结果
对4项涉及187592名参与者和9456例发病病例的前瞻性队列研究进行的荟萃分析表明，总维生素D摄入量与2型糖尿病风险之间不存在显著关联。合并相对危险度为0.93（95%可信区间：0.85 - 1.01）。亚组分析的关联相似，饮食维生素D摄入量、补充维生素D摄入量、美国总维生素D摄入量以及仅女性的总维生素D摄入量的合并相对危险度分别为0.94（95%可信区间：0.77 - 1.08）、0.91（95%可信区间：0.77 - 1.08）、0.93（95%可信区间：0.84 - 1.02）和0.92（95%可信区间：0.84 - 1.01）。
结论
我们的结果支持维生素D摄入量与2型糖尿病之间不存在关联。
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