Beiko Darren, Zaza Khaled, Power Kevin V, Siemens D Robert, Boag Alexander H
Department of Urology, Queen's University, Kingston General Hospital, Kingston, ON;
Division of Radiation Oncology, Queen's University, Kingston General Hospital, Kingston, ON;
Can Urol Assoc J. 2014 May;8(5-6):E361-3. doi: 10.5489/cuaj.1692.
Isolated anterior urethral metastases from prostate cancer are rare. The pathogenesis of this form of loco-regional recurrence may be related to spread by instrumentation-induced implantation and could potentially then be associated with a better prognosis than metastatic disease secondary to a more malignant phenotype. We report a case of a 68-year-old man with high-risk prostate cancer, diagnosed at transurethral resection of prostate, who was originally treated with combination external beam radiotherapy and hormonal therapy. He re-presented 4 years after his original diagnosis with recurrent gross hematuria and cystourethroscopic biopsies of anterior urethral polyps revealing isolated recurrent prostatic adenocarcinoma. We present our this case and review the literature.
前列腺癌孤立性前尿道转移罕见。这种局部区域复发形式的发病机制可能与器械操作诱导种植播散有关，相较于继发于更恶性表型的转移性疾病，其预后可能更好。我们报告一例68岁高危前列腺癌男性病例，该患者在经尿道前列腺切除术中被诊断，最初接受了外照射放疗和激素治疗联合方案。在初次诊断4年后，他因复发性肉眼血尿再次就诊，前尿道息肉的膀胱尿道镜活检显示为孤立性复发性前列腺腺癌。我们展示此病例并复习相关文献。
