Hong Keum-Shik, Nguyen Hoang-Dung
Department of Cogno-Mechatronics Engineering, Pusan National University; 2 Busandaehak-ro, Geumjeong-gu, Busan 609-735, South Korea ; School of Mechanical Engineering, Pusan National University; 2 Busandaehak-ro, Geumjeong-gu, Busan 609-735, South Korea.
Department of Cogno-Mechatronics Engineering, Pusan National University; 2 Busandaehak-ro, Geumjeong-gu, Busan 609-735, South Korea.
Biomed Opt Express. 2014 May 9;5(6):1778-98. doi: 10.1364/BOE.5.001778. eCollection 2014 Jun 1.
THE PAPER PRESENTS STATE SPACE MODELS OF THE HEMODYNAMIC RESPONSE (HR) OF FNIRS TO AN IMPULSE STIMULUS IN THREE BRAIN REGIONS: motor cortex (MC), somatosensory cortex (SC), and visual cortex (VC). Nineteen healthy subjects were examined. For each cortex, three impulse HRs experimentally obtained were averaged. The averaged signal was converted to a state space equation by using the subspace method. The activation peak and the undershoot peak of the oxy-hemoglobin (HbO) in MC are noticeably higher than those in SC and VC. The time-to-peaks of the HbO in three brain regions are almost the same (about 6.76 76 ± 0.2 s). The time to undershoot peak in VC is the largest among three. The HbO decreases in the early stage (~0.46 s) in MC and VC, but it is not so in SC. These findings were well described with the developed state space equations. Another advantage of the proposed method is its easy applicability in generating the expected HR to arbitrary stimuli in an online (or real-time) imaging. Experimental results are demonstrated.
本文介绍了功能近红外光谱（FNIRS）在运动皮层（MC）、体感皮层（SC）和视觉皮层（VC）三个脑区对脉冲刺激的血流动力学反应（HR）的状态空间模型。对19名健康受试者进行了检查。对于每个皮层，将实验获得的三个脉冲HR进行平均。通过子空间方法将平均信号转换为状态空间方程。运动皮层中氧合血红蛋白（HbO）的激活峰值和下冲峰值明显高于体感皮层和视觉皮层。三个脑区中HbO的峰值时间几乎相同（约6.76±0.2秒）。视觉皮层的下冲峰值时间在三者中最长。运动皮层和视觉皮层中HbO在早期（约0.46秒）下降，但体感皮层并非如此。这些发现可以通过所建立的状态空间方程得到很好的描述。该方法的另一个优点是易于应用于在线（或实时）成像中生成对任意刺激的预期HR。文中展示了实验结果。
