Re Rebecca, Contini Davide, Turola Massimo, Spinelli Lorenzo, Zucchelli Lucia, Caffini Matteo, Cubeddu Rinaldo, Torricelli Alessandro
Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
Biomed Opt Express. 2013 Sep 24;4(10):2231-46. doi: 10.1364/BOE.4.002231. eCollection 2013.
We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment.
我们基于时域功能近红外光谱技术，设计了一种用于肌肉和脑部成像的紧凑型双波长（687纳米、826纳米）多通道（16个光源、8个探测器）医疗设备。该系统采用波长空间复用方法来减少波长串扰并提高信噪比。按照专门为光子迁移仪器设计的协议，在均匀和非均匀组织模型上测试了系统性能。已进行初步体内测量，以验证该仪器监测动脉闭塞期间手臂肌肉以及运动任务实验期间成人大脑血液动力学参数变化的能力。
