在强散射介质中对稀土上转换纳米颗粒的可视化研究
Visualization of upconverting nanoparticles in strongly scattering media.
作者信息
Khaydukov E V, Semchishen V A, Seminogov V N, Nechaev A V, Zvyagin A V, Sokolov V I, Akhmanov A S, Panchenko V Ya
机构信息
Institute on Laser and Information Technologies of the Russian Academy of Sciences, City of Shatura, Moscow Region, Svyatoozerskaya ul. 1, 140700, Russia.
Institute on Laser and Information Technologies of the Russian Academy of Sciences, City of Shatura, Moscow Region, Svyatoozerskaya ul. 1, 140700, Russia ; M.V. Lomonosov Moscow State University of Fine Chemical Technologies, Moscow, prospekt Vernadskogo 86, 119541, Russia.
出版信息
Biomed Opt Express. 2014 May 28;5(6):1952-64. doi: 10.1364/BOE.5.001952. eCollection 2014 Jun 1.
Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF4:Yb(3+)Tm(3+)@NaYF4 core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.
在医学应用中，需要光学可视化系统来确定生物组织中深层发光标记物的位置。此类系统的空间分辨率受组织散射的限制。我们提出了一种新型落射发光技术，与传统可视化技术相比，在确定散射介质深处标记物的位置时，该技术可使横向空间分辨率提高1.8倍。通过使用NaYF4:Yb(3+)Tm(3+)@NaYF4核壳纳米颗粒和具有用于激发和检测反斯托克斯发光信号的组合通道的特殊光纤探头来实现这一目标。
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