一种具有聚集诱导发光（AIE）特性的荧光点亮探针，用于特异性线粒体成像以识别分化的棕色脂肪细胞。
A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells.
作者信息
Gao Meng, Sim Choon Kiat, Leung Chris Wai Tung, Hu Qinglian, Feng Guangxue, Xu Feng, Tang Ben Zhong, Liu Bin
机构信息
Institute of Materials Research and Engineering (A*STAR), 3 Research Link, Singapore 117602.
出版信息
Chem Commun (Camb). 2014 Aug 7;50(61):8312-5. doi: 10.1039/c4cc00452c.
We report the design and synthesis of a specific mitochondrial fluorescent probe AIE-MitoGreen-1 with AIE characteristics to monitor the mitochondrial morphology changes and identify the differentiation process of living brown adipose cells. The probe AIE-MitoGreen-1 has significant advantages such as high cellpermeability, good mitochondrial retention, low background fluorescence, large Stokes shift, and low toxicity.
我们报道了一种具有聚集诱导发光（AIE）特性的特异性线粒体荧光探针AIE-MitoGreen-1的设计与合成，用于监测线粒体形态变化并识别活的棕色脂肪细胞的分化过程。探针AIE-MitoGreen-1具有显著优势，如高细胞通透性、良好的线粒体保留能力、低背景荧光、大斯托克斯位移和低毒性。
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