Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering , University of Jinan , Jinan , Shandong 250022 , P. R. China.
Anal Chem. 2019 Feb 5;91(3):1715-1718. doi: 10.1021/acs.analchem.8b05305. Epub 2019 Jan 9.
The expression of the genetic information on protein is achieved by mitochondrial RNA (mtRNA). However, mtRNA tracking in biological systems is bound due to the lack of an effective method. To solve this pressing problem, we construct a low molecular weight probe MR-IDE to track endogenous mtRNA in the cancer cells and macrophages for the first time.
蛋白质上的遗传信息表达是通过线粒体 RNA（mtRNA）实现的。然而，由于缺乏有效的方法，mtRNA 在生物系统中的追踪受到限制。为了解决这个紧迫的问题，我们首次构建了一种小分子探针 MR-IDE，以追踪癌细胞和巨噬细胞中的内源性 mtRNA。
