Jain Ankita, Jain Priyanka, Kurmi Jaya, Jain Darshana, Jain Roshni, Chandel Silky, Sahu Anamika, Mody Nishi, Upadhaya Satish, Jain Aviral
Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.), 470002 India.
Crit Rev Ther Drug Carrier Syst. 2014;31(3):219-72. doi: 10.1615/critrevtherdrugcarriersyst.2014008126.
Skin is the largest and easily accessible organ of the body and therefore can be extensively used as a prominent route of delivery for local and systemic effects. Though it presents a multifunctional barrier between body and surrounding particles, there are chances to deliver therapeutic nanocarrier, particularly in diseased skin. Both for dermal and transdermal drug delivery, the horny layer, i.e., the uppermost layer of the skin serve as the most resistant layer to be crossed and for this purpose, different perforation techniques are used that relatively widen the skin opening and allow the passage of drug (≤ 10 mg) and micromolecules, but this amateur disruption of the skin can be avoided in order to preserve this barrier against cutaneous microbiota by using deformable nanocarriers. In this review, we discuss the nanosized aggregates and microneedle technology for the advanced delivery of vaccines, protein, peptides, nucleic acid, and hormone across the skin.
皮肤是人体最大且易于触及的器官，因此可广泛用作实现局部和全身效应的重要给药途径。尽管皮肤在人体与周围微粒之间构成了多功能屏障，但仍有机会递送治疗性纳米载体，尤其是在患病皮肤中。对于真皮给药和透皮给药而言，角质层，即皮肤的最外层，是最难穿透的一层，为此人们采用了不同的穿孔技术，这些技术相对扩大了皮肤开口，使药物（≤10毫克）和小分子能够通过，但为了保护皮肤屏障抵御皮肤微生物群，可通过使用可变形纳米载体来避免这种对皮肤的人为破坏。在本综述中，我们讨论了纳米聚集体和微针技术，用于疫苗、蛋白质、肽、核酸和激素经皮的先进递送。
