Gasper David J, Tejera Melba Marie, Suresh M
Department of Pathobiological Sciences; Comparative Biomedical Sciences Graduate Program, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Crit Rev Immunol. 2014;34(2):121-46. doi: 10.1615/critrevimmunol.2014010373.
Immunologic memory is the adaptive immune system's powerful ability to remember a previous antigen encounter and react with accelerated vigor upon antigen re-exposure. It provides durable protection against reinfection with pathogens and is the foundation for vaccine-induced immunity. Unlike the relatively restricted immunologic purview of memory B cells and CD8 T cells, the field of CD4 T-cell memory must account for multiple distinct lineages with diverse effector functions, the issue of lineage commitment and plasticity, and the variable distribution of memory cells within each lineage. Here, we discuss the evidence for lineage-specific CD4 T-cell memory and summarize the known factors contributing to memory-cell generation, plasticity, and long-term maintenance.
免疫记忆是适应性免疫系统强大的能力，能够记住先前遇到的抗原，并在再次接触抗原时以更快的活力做出反应。它为抵御病原体的再次感染提供持久保护，是疫苗诱导免疫的基础。与记忆B细胞和CD8 T细胞相对受限的免疫范围不同，CD4 T细胞记忆领域必须考虑具有多种效应功能的多个不同谱系、谱系定向和可塑性问题，以及每个谱系内记忆细胞的可变分布。在这里，我们讨论了谱系特异性CD4 T细胞记忆的证据，并总结了有助于记忆细胞生成、可塑性和长期维持的已知因素。
