Marleau Sylvie, Mellal Katia, Huynh David N, Ong Huy
Faculté de Pharmacie, Université de Montréal, Montréal, Qué., Canada.
Front Horm Res. 2014;43:93-106. doi: 10.1159/000360568. Epub 2014 Jun 10.
Atherosclerosis is the main underlying cause of ischemic heart disease and related acute cardiovascular complications, including myocardial infarction and stroke. In view of the failure of statins to demonstrate a beneficial effect in all patients, exhaustive research efforts have unfold into different research avenues, in close relation to the increase in basic knowledge regarding lipoprotein metabolism, macrophage function and inflammatory conditions associated with atherosclerosis. This review focuses specifically on potential therapeutic peptides targeting dyslipidemia, macrophage scavenger receptors, cholesterol metabolism and anti-inflammatory cytokines as novel therapeutic avenues in atherosclerosis.
动脉粥样硬化是缺血性心脏病及相关急性心血管并发症（包括心肌梗死和中风）的主要潜在病因。鉴于他汀类药物未能在所有患者中显示出有益效果，随着有关脂蛋白代谢、巨噬细胞功能以及与动脉粥样硬化相关的炎症状态的基础知识不断增加，大量研究工作已展开并涉及不同的研究途径。本综述特别关注靶向血脂异常、巨噬细胞清道夫受体、胆固醇代谢和抗炎细胞因子的潜在治疗性肽，将其作为动脉粥样硬化的新型治疗途径。
