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经皮睾酮预处理对接受体外受精/卵胞浆内单精子注射的卵巢低反应者的影响：一项荟萃分析。

Effect of pretreatment with transdermal testosterone on poor ovarian responders undergoing IVF/ICSI: A meta-analysis.

作者信息

Luo Shan, Li Shangwei, Li Xiaohong, Qin Lang, Jin Song

机构信息

Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.

出版信息

Exp Ther Med. 2014 Jul;8(1):187-194. doi: 10.3892/etm.2014.1683. Epub 2014 Apr 14.

DOI:10.3892/etm.2014.1683
PMID:24944620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4061182/
Abstract

In order to identify and describe the effectiveness of transdermal testosterone pretreatment on poor ovarian responders, MEDLINE, EMBASE, the Cochrane library and the Chinese biomedical database were searched for randomized controlled trials (RCTs). Three RCTs, which compared the outcomes of female pretreatment with transdermal testosterone prior to fertilization/intracytoplasmic sperm injection (IVF/ICSI) with those of control groups, were included in the present review. The three RCTs enrolled a total of 221 randomized subjects. The meta-analysis revealed that females who received transdermal testosterone treatment prior to their IVF/ICSI cycle had a two-fold increase in live birth rate [risk ratio (RR)=2.01, 95% confidence interval (CI) 1.03-3.91], clinical pregnancy rate (RR=2.09, 95% CI 1.14-3.81) and a significantly more oocyte retrieved [mean difference (MD)=1.36, 95% CI 0.82-1.90]. The current findings provide evidence that pretreatment with transdermal testosterone may improve the clinical outcomes for poor ovarian responders undergoing IVF/ICSI. However, the results should be interpreted with caution due to the small sample size of the studies used and the heterogeneities. Further good quality RCTs would be needed to reach further conclusions.

摘要

为了确定并描述经皮睾酮预处理对卵巢低反应者的有效性，我们检索了MEDLINE、EMBASE、Cochrane图书馆和中国生物医学数据库，以查找随机对照试验（RCT）。本综述纳入了三项RCT，这些研究比较了在受精/卵胞浆内单精子注射（IVF/ICSI）前接受经皮睾酮预处理的女性与对照组的结局。这三项RCT共纳入了221名随机受试者。荟萃分析显示，在IVF/ICSI周期前接受经皮睾酮治疗的女性，其活产率增加了两倍[风险比（RR）=2.01，95%置信区间（CI）1.03 - 3.91]，临床妊娠率（RR = 2.09，95% CI 1.14 - 3.81），并且回收的卵母细胞明显更多[平均差（MD）=1.36，95% CI 0.82 - 1.90]。目前的研究结果表明，经皮睾酮预处理可能会改善接受IVF/ICSI的卵巢低反应者的临床结局。然而，由于所用研究的样本量较小且存在异质性，对结果的解释应谨慎。需要进一步开展高质量的RCT才能得出进一步的结论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/68c5db4510bb/ETM-08-01-0187-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/2d283a96221c/ETM-08-01-0187-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/5ac3938f7a0c/ETM-08-01-0187-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/12df27a4c9f8/ETM-08-01-0187-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/04b208e1cf05/ETM-08-01-0187-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/c114a21e352a/ETM-08-01-0187-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/10e148332cd2/ETM-08-01-0187-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/68c5db4510bb/ETM-08-01-0187-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/2d283a96221c/ETM-08-01-0187-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/5ac3938f7a0c/ETM-08-01-0187-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/12df27a4c9f8/ETM-08-01-0187-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/04b208e1cf05/ETM-08-01-0187-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/c114a21e352a/ETM-08-01-0187-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/10e148332cd2/ETM-08-01-0187-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b0/4061182/68c5db4510bb/ETM-08-01-0187-g06.jpg

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