Dong Ruiying, Pang Yingxin, Mao Hongluan, Yang Ning, Liu Peishu
Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Oncol Lett. 2014 Apr;7(4):1039-1042. doi: 10.3892/ol.2014.1858. Epub 2014 Feb 7.
It is uncommon that fertility is preserved in young nulliparous females with low-grade endometrial stromal sarcoma (ESS). Therefore, successful pregnancy following such conservative management has been rarely reported in previous literature. A 25-year-old female (gravida, 0; para, 0) underwent hysteroscopic surgery and was pathologically diagnosed with an endometrial stromal nodule. The patient underwent fertility-preserving local resection and uterine reconstruction, with a final pathological diagnosis of low-grade ESS. Endocrine therapy was then administered. Conservative management resulted in the complete remission of low-grade ESS. The patient naturally conceived and successfully delivered a healthy baby at 42 weeks' gestation by cesarean section, ~30 months following diagnosis with low-grade ESS. In conclusion, conservative management, including fertility-preserving local mass resection and endocrine therapy, can be effective for low-grade ESS and may yield a favorable outcome for young nulliparous females desiring fertility preservation.
年轻未生育的低级别子宫内膜间质肉瘤（ESS）女性患者保留生育功能的情况并不常见。因此，以往文献中很少报道此类保守治疗后成功妊娠的案例。一名25岁女性（孕0产0）接受了宫腔镜手术，病理诊断为子宫内膜间质结节。患者接受了保留生育功能的局部切除及子宫重建，最终病理诊断为低级别ESS。随后给予内分泌治疗。保守治疗使低级别ESS完全缓解。患者自然受孕，并在诊断为低级别ESS约30个月后，于孕42周时通过剖宫产成功产下一名健康婴儿。总之，包括保留生育功能的局部肿物切除及内分泌治疗在内的保守治疗，对低级别ESS可能有效，对于渴望保留生育功能的年轻未生育女性可能会产生良好的结局。
