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一组腹盆腔孤立性纤维瘤病例的临床病理特征

Clinicopathological findings in a case series of abdominopelvic solitary fibrous tumors.

作者信息

Wang Hao, Chen Ping, Zhao Wei, Shi Lei, Gu Xuewen, Xu Qing

机构信息

Department of Gastrointestinal Surgery, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.

Department of Pathology, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.

出版信息

Oncol Lett. 2014 Apr;7(4):1067-1072. doi: 10.3892/ol.2014.1872. Epub 2014 Feb 11.

Abstract

Solitary fibrous tumors (SFTs) represent a rare type of soft tissue tumor. Extrathoracic SFTs (ESFTs) in the soft tissues of the abdominopelvic cavity are extremely rare. Between January 2002 and January 2013, 10 patients were identified with abdominopelvic SFTs at the Northern Jiangsu People's Hospital. The clinicopathological data, treatment and follow-up results were retrospectively analyzed in this study. Patients included four females and six males, whose age ranged between 21 and 75 years (mean, 53.3 years). The maximum diameter of the tumors was 2.5-28 cm (mean, 12.7 cm). Two cases were diagnosed as malignant variants of ESFTs. R resection was performed in eight patients, while one patient underwent R resection, and one patient received palliative chemotherapy for an inoperable mass. Follow-up time ranged between 6 and 126 months (mean, 50 months). The patient with R resection suffered a local relapse, and the patient receiving palliative chemotherapy succumbed to the disease. The remaining eight patients remained free of disease. Abdominopelvic SFTs usually reveal an indolent process, although the majority of tumors in the present study were of giant size when diagnosed. The risk of local recurrence and metastasis correlates with tumor size and the histological status of surgical margins. The preferred treatment is complete resection followed by extended follow-up surveillance.

摘要

孤立性纤维性肿瘤(SFTs)是一种罕见的软组织肿瘤。腹腔盆腔软组织中的胸外孤立性纤维性肿瘤(ESFTs)极为罕见。2002年1月至2013年1月期间,苏北人民医院共确诊10例腹腔盆腔SFTs患者。本研究对其临床病理资料、治疗及随访结果进行了回顾性分析。患者包括4名女性和6名男性,年龄在21岁至75岁之间(平均53.3岁)。肿瘤最大直径为2.5 - 28 cm(平均12.7 cm)。2例被诊断为ESFTs的恶性变体。8例患者接受了R切除,1例患者接受了R切除,1例患者因肿块无法切除而接受姑息化疗。随访时间为6至126个月(平均50个月)。接受R切除的患者出现局部复发,接受姑息化疗的患者死于该疾病。其余8例患者无疾病复发。腹腔盆腔SFTs通常病程进展缓慢,尽管本研究中的大多数肿瘤在诊断时体积巨大。局部复发和转移的风险与肿瘤大小及手术切缘的组织学状态相关。首选治疗方法是完整切除,随后进行长期随访监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/377e/3961353/d31f30d9c0b2/OL-07-04-1067-g00.jpg

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