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与睾丸特异性、黄蜂毒液和致病相关蛋白-1在胶质母细胞瘤中受甲基化调控。

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma.

作者信息

Jacoby Elad, Yalon Michal, Leitner Moshe, Cohen Zvi R, Cohen Yehudit, Fisher Tamar, Eder Sarit, Amariglio Ninette, Rechavi Gideon, Cazacu Simona, Xiang Cunli, Mikkelsen Tom, Brodie Chaya, Toren Amos

机构信息

Department of Pediatric Hematology and Oncology, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel ; Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.

Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.

出版信息

Oncol Lett. 2014 Apr;7(4):1209-1212. doi: 10.3892/ol.2014.1829. Epub 2014 Jan 27.

DOI:10.3892/ol.2014.1829
PMID:24944694
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3961359/
Abstract

Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

摘要

睾丸特异性黄蜂毒液和致病相关蛋白-1（RTVP-1），也被称为胶质瘤致病相关蛋白1，在胶质母细胞瘤（GBM；世界卫生组织IV级）中高表达且具有致癌特性。已发现启动子甲基化可控制前列腺癌、肾母细胞瘤、急性髓系白血病和黑色素瘤中RTVP-1的表达。在这项双机构研究中，检测了星形细胞脑恶性肿瘤（GBM和少突胶质细胞瘤）中RTVP-1的甲基化状态。与非肿瘤脑样本相比，GBM中RTVP-1启动子呈低甲基化，但在少突胶质细胞瘤中呈高甲基化。RTVP-1甲基化与mRNA水平的RTVP-1表达相关。在GBM中，RTVP-1启动子的高甲基化与总体生存率的改善相关，尽管无统计学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/51ea6c9af323/OL-07-04-1209-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/22e1575720ee/OL-07-04-1209-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/c12e0f11a18c/OL-07-04-1209-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/51ea6c9af323/OL-07-04-1209-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/22e1575720ee/OL-07-04-1209-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/c12e0f11a18c/OL-07-04-1209-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b68/3961359/51ea6c9af323/OL-07-04-1209-g02.jpg

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Comparison of survival between cerebellar and supratentorial glioblastoma patients: surveillance, epidemiology, and end results (SEER) analysis.
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