Wu Fang, Qu Lu, Tan Yafen, Zhang Yue, Hu Chunhong
Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Oncol Lett. 2014 Apr;7(4):1305-1307. doi: 10.3892/ol.2014.1871. Epub 2014 Feb 11.
L-asparaginase (L-Asp)-associated pancreatitis (AAP) occurs occasionally; however, this side-effect has predominantly been observed among pediatric patients. Usually, it is not life-threatening and generally responds to intensive medical therapy. The present study presents a rare case of lethal AAP in an adult. The patient was recently diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, and the chronic hepatitis B virus (HBV) infection and was receiving L-Asp as part of a chemotherapy regimen. Severe acute pancreatitis occurred and the patient succumbed 72 h after completion of chemotherapy. The HBV infection and lipid disorders may have been potential risk factors for the development of severe acute pancreatitis in the patient.
L-天冬酰胺酶（L-Asp）相关性胰腺炎（AAP）偶尔会发生；然而，这种副作用主要在儿科患者中观察到。通常，它不会危及生命，一般对强化药物治疗有反应。本研究报告了一例成人致死性AAP的罕见病例。该患者最近被诊断为鼻型结外自然杀伤/T细胞淋巴瘤（ENKTL）以及慢性乙型肝炎病毒（HBV）感染，正在接受L-Asp作为化疗方案的一部分。发生了严重急性胰腺炎，患者在化疗结束后72小时死亡。HBV感染和脂质紊乱可能是该患者发生严重急性胰腺炎的潜在危险因素。
