Onwuli Donatus Onukwufor, Brown Holy, Ozoani Harrison Anaezichukwuolu
Chemical Pathology Unit, Department of Medical Laboratory Science, Faculty of Science, Rivers State University of Science and Technology, Nkpolu Oroworukwo, Port Harcourt, Rivers State, Nigeria.
ISRN Endocrinol. 2014 May 6;2014:124974. doi: 10.1155/2014/124974. eCollection 2014.
The antihyperglycaemic activity of Tetracarpidium conophorum nut (walnut) was investigated in albino rats. A total of 20 albino rats were used for the study. The rats were divided into five groups (A-E) of four rats each. Diabetes were induced in the rats except four which served as the positive control group A. Groups B (negative control), C, D, and E contain diabetic rats each with blood sugar level ≥17.00 mmol/L. Groups A and B were fed on 85.2 g of top feed grower over the test period. Test groups C, D, and E were fed on 21.3 g, 42.6 g, and 85.2 g of walnuts, respectively, and their fasting blood sugar (FBS) levels were checked on daily basis. Fasting blood glucose levels of the test groups were significantly lower than negative control P < 0.05, for 3rd, 7th, and 10th days of the test. There were also significant increase in the body weight and hemoglobin concentration and a decreased urine output of the test group compared with the controls. These results indicate that Tetracarpidium conophorum nut (walnut) has an antihyperglycemic effect in diabetic rats.
对白化大鼠进行了锥花檀坚果（核桃）降血糖活性的研究。本研究共使用了20只白化大鼠。大鼠被分为五组（A - E），每组四只。除作为阳性对照组A的四只大鼠外，其余大鼠均诱导糖尿病。B组（阴性对照）、C组、D组和E组均为糖尿病大鼠，血糖水平≥17.00 mmol/L。在试验期间，A组和B组大鼠喂食85.2克生长育肥料。试验组C、D和E分别喂食21.3克、42.6克和85.2克核桃，并每天检查它们的空腹血糖（FBS）水平。在试验的第3天、第7天和第10天，试验组的空腹血糖水平显著低于阴性对照组，P < 0.05。与对照组相比，试验组的体重、血红蛋白浓度也显著增加，尿量减少。这些结果表明，锥花檀坚果（核桃）对糖尿病大鼠具有降血糖作用。
