Kibirige Davis
Department of Medicine, Uganda Martyrs Hospital Lubaga, Kampala, Uganda.
Indian J Endocrinol Metab. 2014 May;18(3):288-94. doi: 10.4103/2230-8210.131136.
A broad spectrum of endocrine conditions has been reported among adult patients with tuberculosis in Africa. This review aims to describe the magnitude and pathogenesis of the following endocrinopathies among patients with tuberculosis in Africa: adrenal insufficiency, diabetes mellitus, disorders of calcium and vitamin D metabolism, thyroid dysfunction and hypogonadism. PubMed database and Google scholar were used to search for the relevant published English language studies and case reports relating to endocrine abnormalities and tuberculosis in Africa up to July 2013. The search terms used were endocrine dysfunction, endocrine abnormalities, adrenal insufficiency, diabetes mellitus, thyroid dysfunction, hypogonadism, disorders of calcium and vitamin D metabolism, tuberculosis, Africa. Reference lists of the identified articles were further used to identify other studies. Adrenal insufficiency, diabetes mellitus and calcium-vitamin D abnormalities were the most prevalent and frequently reported endocrine disorders among adult patients with tuberculosis in Africa. A meticulous endocrine evaluation among tuberculosis patients with suspected endocrine abnormalities should be encouraged in Africa and other high TB endemic regions. Treatment of these endocrine disorders has generally been shown to improve quality of life and reduce mortality.
在非洲，成年结核病患者中已报告了广泛的内分泌疾病。本综述旨在描述非洲结核病患者中以下内分泌疾病的严重程度和发病机制：肾上腺功能不全、糖尿病、钙和维生素D代谢紊乱、甲状腺功能障碍和性腺功能减退。利用PubMed数据库和谷歌学术搜索截至2013年7月与非洲内分泌异常和结核病相关的已发表英文研究及病例报告。使用的搜索词为内分泌功能障碍、内分泌异常、肾上腺功能不全、糖尿病、甲状腺功能障碍、性腺功能减退、钙和维生素D代谢紊乱、结核病、非洲。已识别文章的参考文献列表进一步用于识别其他研究。肾上腺功能不全、糖尿病和钙-维生素D异常是非洲成年结核病患者中最普遍且报道频繁的内分泌疾病。在非洲和其他结核病高流行地区，应鼓励对疑似内分泌异常的结核病患者进行细致的内分泌评估。这些内分泌疾病的治疗总体上已显示可改善生活质量并降低死亡率。
