Takagi H, Umemoto T
Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan -
Int Angiol. 2015 Aug;34(4):383-91. Epub 2014 Jun 19.
The aim of this paper was to determine whether obesity is associated with abdominal aortic aneurysm (AAA) presence. We performed the first meta-analysis of currently available studies.
MEDLINE and EMBASE were searched through January 2014. Eligible studies were comparative studies comparing body mass index (BMI) in patients with AAA to that in subjects without AAA or estimating a relative risk of AAA prevalence for subjects with obesity (high BMI).
Of 183 potentially relevant articles screened initially, 19 eligible studies enrolling 29,120 patients with AAA and 3,163,575 subjects without AAA were identified and included. A pooled analysis demonstrated no statistically significant difference between BMI in the AAA group and that in the control group: mean difference, 0.46 kg/m2; 95% confidence interval, -0.07 to 1.00 kg/m2; P=0.09. Another pooled analysis demonstrated that obesity was unassociated with a statistically significant increase in AAA prevalence: odds ratio, 1.07; 95% confidence interval, 0.94 to 1.22; P=0.30. There was no evidence of significant publication bias: P=0.69 and 0.90 for mean difference and odds ratio, respectively.
Obesity appears to be unassociated with AAA presence.
本文旨在确定肥胖是否与腹主动脉瘤（AAA）的存在相关。我们对现有研究进行了首次荟萃分析。
检索截至2014年1月的MEDLINE和EMBASE数据库。纳入的研究为比较AAA患者与非AAA受试者体重指数（BMI）的对照研究，或评估肥胖（高BMI）受试者患AAA的相对风险。
在最初筛选的183篇可能相关的文章中，确定并纳入了19项符合条件的研究，共纳入29120例AAA患者和3163575例非AAA受试者。汇总分析显示，AAA组与对照组的BMI之间无统计学显著差异：平均差异为0.46kg/m²；95%置信区间为-0.07至1.00kg/m²；P=0.09。另一项汇总分析表明，肥胖与AAA患病率的统计学显著增加无关：优势比为1.07；95%置信区间为0.94至1.22；P=0.30。没有证据表明存在显著的发表偏倚：平均差异和优势比的P值分别为0.69和0.90。
肥胖似乎与腹主动脉瘤的存在无关。
