Singh Vineeta, Gupta Purva, Pande Veena
National Institute of Malaria Research (ICMR), Dwarka, New Delhi, India.
J Vector Borne Dis. 2014 Jun;51(2):75-81.
Malaria is an infectious disease that is widespread in tropical and subtropical regions. The malaria parasite is able to skip the host immunity and thus maintains not only persistent but also repeated infections. There are a number of multigene families in Plasmodium that code for the variant antigens and are targets for protective immunity. In this article, we summarize the virulence genes of P. falciparum (var genes) and P. vivax (vir genes) which play key roles in disease pathogenesis by evading elimination by the host immune system. These genes occurring within the parasite population are mostly present in the subtelomeric regions of the chromosome.
疟疾是一种在热带和亚热带地区广泛传播的传染病。疟原虫能够避开宿主免疫，因此不仅能维持持续性感染，还能反复感染。疟原虫中有许多多基因家族，它们编码变异抗原，是保护性免疫的靶点。在本文中，我们总结了恶性疟原虫（var基因）和间日疟原虫（vir基因）的毒力基因，这些基因通过逃避宿主免疫系统的清除在疾病发病机制中起关键作用。这些存在于寄生虫群体中的基因大多位于染色体的亚端粒区域。
