Fiedler Lorna R, Maifoshie Evie, Schneider Michael D
British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College London, London, UK.
British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College London, London, UK.
Curr Top Dev Biol. 2014;109:171-247. doi: 10.1016/B978-0-12-397920-9.00002-0.
Heart failure is one of the paramount global causes of morbidity and mortality. Despite this pandemic need, the available clinical counter-measures have not altered substantially in recent decades, most notably in the context of pharmacological interventions. Cell death plays a causal role in heart failure, and its inhibition poses a promising approach that has not been thoroughly explored. In previous approaches to target discovery, clinical failures have reflected a deficiency in mechanistic understanding, and in some instances, failure to systematically translate laboratory findings toward the clinic. Here, we review diverse mouse models of heart failure, with an emphasis on those that identify potential targets for pharmacological inhibition of cell death, and on how their translation into effective therapies might be improved in the future.
心力衰竭是全球发病和死亡的主要原因之一。尽管有这种普遍需求，但近几十年来可用的临床对策并未发生实质性改变，在药物干预方面尤为明显。细胞死亡在心力衰竭中起因果作用，抑制细胞死亡是一种有前景但尚未得到充分探索的方法。在以往的靶点发现方法中，临床失败反映了对机制理解的不足，在某些情况下，未能将实验室研究结果系统地转化为临床应用。在这里，我们综述了多种心力衰竭小鼠模型，重点关注那些可识别细胞死亡药物抑制潜在靶点的模型，以及未来如何更好地将其转化为有效治疗方法。
